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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Maturational Changes in Peripheral Lymphocyte Subsets Pertinent to Monitoring Human Immunodeficiency Virus-Infected Chinese Pediatric Patients
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Maturational Changes in Peripheral Lymphocyte Subsets Pertinent to Monitoring Human Immunodeficiency Virus-Infected Chinese Pediatric Patients

机译：与监测人类免疫缺陷病毒感染的中国儿童患者有关的外周血淋巴细胞亚群的成熟变化

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摘要

On the basis of results of testing of 212 peripheral blood samples from ethnic Chinese individuals in five age groups, ranging from birth to adulthood, by standardized flow cytometry techniques, we studied the maturational processes that are pertinent to monitoring the human immunodeficiency virus (HIV)-infected Chinese pediatric population. While the numbers of peripheral total white cells and percent lymphocytes declined from birth to adulthood, the percent CD3+ T lymphocytes was steady among all age groups studied. The numbers of CD3+ CD4+ (T-helper) cells decreased markedly after the first year of life, followed by a slower decline afterward and then a slight increase before adulthood. The trend for CD3+ CD8+ (T-suppressor) cells, however, was an increase among individuals of all age ranges. The numbers of CD19+ CD3? (B cells) increased only during the first year of life and then declined steadily, while natural killer (NK) cells showed the opposite pattern. Comparison of the results with those of studies done with a Caucasian population showed that both peripheral T-helper and T-suppressor cell numbers were low after the first year of life in the Chinese pediatric population in comparison with those in a Caucasian pediatric population. Lower B-cell counts and higher NK-cell counts were seen after the first year of life in the Chinese population than in the Caucasian population. It is important that for each HIV-infected population normative ranges of the lymphocyte subset be established to monitor HIV-infected pediatric patients.
机译：根据标准化流式细胞仪技术对从出生到成年的五个年龄组的212名中国人的外周血样本进行测试的结果，我们研究了与监测人类免疫缺陷病毒（HIV）有关的成熟过程感染的中国儿童人群。从出生到成年，外周血总白细胞和淋巴细胞百分比下降，而在所有研究年龄组中，CD3 + T淋巴细胞百分比均保持稳定。出生后第一年，CD3 + CD4 + （T-helper）细胞的数目明显减少，随后缓慢下降，然后在成年前略有增加。但是，CD3 + CD8 + （T抑制子）细胞的趋势在所有年龄段的个体中都有所增加。 CD19 + CD3 ？（B细胞）的数量仅在生命的第一年增加，然后稳定下降，而自然杀伤（NK）细胞则呈现相反的模式。结果与白人人群的研究结果比较表明，与白人人群相比，中国儿童人群出生后第一年的外周T辅助细胞和T抑制细胞数量均较低。与白种人相比，出生后第一年中国人的B细胞计数较低，而NK细胞计数较高。重要的是，应为每个感染HIV的人群建立淋巴细胞亚群的规范范围，以监测感染HIV的小儿患者。

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