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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Increasing doses of purified influenza virus hemagglutinin and subvirion vaccines enhance antibody responses in the elderly.
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Increasing doses of purified influenza virus hemagglutinin and subvirion vaccines enhance antibody responses in the elderly.

机译：纯化流感病毒血凝素和亚病毒颗粒疫苗的剂量增加，可增强老年人的抗体反应。

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The reactogenicities and immunogenicities of two influenza virus vaccines were compared in a placebo-controlled clinical trial among healthy ambulatory persons > or = 65 years old (mean age, 72 years). Volunteers were assigned randomly to receive 15-, 45-, or 135-micrograms doses of monovalent influenza A/Taiwan (H1N1) hemagglutinin (HA) or subvirion (SV) vaccine intramuscularly or a placebo. Increasing doses of SV vaccine were associated with a higher rate of injection site discomfort (P < 0.05; chi-square test for linear trend), but all doses of both vaccines were well tolerated. Increasing the dose of the HA or the SV vaccine resulted in increasingly higher postimmunization levels of serum hemagglutination inhibition and neutralizing antibody levels (P < 0.001; multiple linear regression). Mean serum antibody titers at 1 month increased two- to threefold with a ninefold increase in dose; the frequencies of fourfold or greater rises in titer likewise increased. An increase in the dose of the HA or the SV vaccine also resulted in increased frequencies of rises in immunoglobulin A or G antibody titers in nasal wash specimens. The frequencies increased approximately twofold for each vaccine with a ninefold increase in the dose. These data suggest that increasing the HA vaccine dose is a promising approach to the development of improved influenza virus vaccines for use in elderly people.
机译：在安慰剂对照的临床试验中，对≥65岁（平均年龄为72岁）的健康门诊人员进行了两种流感病毒疫苗的反应性和免疫原性比较。随机分配志愿者以肌内或安慰剂方式接受15、45或135毫克剂量的单价A /台湾流感（H1N1）血凝素（HA）或亚病毒体（SV）疫苗。 SV疫苗剂量的增加与注射部位不适的发生率更高相关（P <0.05;线性趋势的卡方检验），但是两种疫苗的所有剂量均具有良好的耐受性。增加HA或SV疫苗的剂量会导致更高的免疫后血清血凝抑制水平和中和抗体水平（P <0.001;多元线性回归）。 1个月时的平均血清抗体滴度增加了2-3倍，剂量增加了9倍。滴度上升四倍或以上的频率也会增加。 HA或SV疫苗剂量的增加还导致洗鼻标本中免疫球蛋白A或G抗体滴度上升的频率增加。每种疫苗的频率增加大约两倍，剂量增加九倍。这些数据表明，增加HA疫苗的剂量是开发用于老年人的改良流感病毒疫苗的有前途的方法。

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