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首页> 外文期刊>CNS neuroscience & therapeutics. >Subfatin is a Novel Adipokine and Unlike Meteorin in Adipose and Brain Expression
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Subfatin is a Novel Adipokine and Unlike Meteorin in Adipose and Brain Expression

机译：Subfatin是一种新型的脂肪因子，在脂肪和大脑表达方面与Meteorin不同

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Summary Aims Adipose tissue releases adipokines that play important roles in metabolic and cardio‐cerebro‐vascular homeostasis. This study was to discover novel adipokines using caloric restriction model. Methods Adipokine candidates were captured by gene array and bioinformatics analysis and verified by preparation of recombinant protein and antibody. Results We established a potential secreted protein database containing 208 genes and identified a novel adipokine, Subfatin, that was the highest expressed in subcutaneous fat of both rodents and humans among 15 detected tissues. The secreted mammalian Subfatin was a glycosylated protein. Subfatin was located diffusely throughout the adipose tissue except lipid droplets, with comparable expression between adipocytes and stromal cells, but much lower expression in macrophages than adipocytes. Subfatin was downregulated in white adipose tissue of caloric restriction rats, whereas dramatically upregulated during white adipocyte differentiation as well as in white adipose tissue of diet‐induced obese mice. Subfatin was annotated as Meteorin‐like (Metrnl) in public databases, a similar transcript of Meteorin (Metrn, also known as glial cell differentiation regulator). Meteorin displayed a brain‐specific expression and was scarce in various adipose tissues, in contrast to the tissue expression patterns of Subfatin. Conclusions Subfatin is a novel adipokine regulated by adipogenesis and obesity, with tissue distribution different from its homologue Meteorin.
机译：概述目的脂肪组织释放在代谢和心脑血管稳态中起重要作用的脂肪因子。本研究旨在利用热量限制模型发现新型脂肪因子。方法通过基因芯片和生物信息学分析捕获脂肪因子候选人，并通过制备重组蛋白和抗体进行验证。结果我们建立了一个包含208个基因的潜在分泌蛋白数据库，并鉴定了一种新的脂肪因子Subfatin，在15种检测到的组织中，其在啮齿动物和人类的皮下脂肪中表达最高。分泌的哺乳动物Subfatin是一种糖基化蛋白。亚脂蛋白分布在整个脂肪组织中，除了脂滴以外，在脂肪细胞和基质细胞之间的表达相当，但在巨噬细胞中的表达要比脂肪细胞低得多。在热量限制大鼠的白色脂肪组织中，subfatin被下调，而在白色脂肪细胞分化以及饮食诱导的肥胖小鼠的白色脂肪组织中，subfatin被显着上调。 Subfatin在公共数据库中被标注为Meteorin-like（Metrnl），是Meteorin（Metrn，也称为神经胶质细胞分化调节剂）的类似转录本。与Subfatin的组织表达模式相反，Meteorin表现出脑特异性表达，并且在各种脂肪组织中都缺乏。结论Subfatin是一种新型的受脂肪生成和肥胖调节的脂肪因子，其组织分布与其同源蛋白Meteorin不同。

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