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首页> 外文期刊>Acta Cirurgica Brasileira >Evaluation of the anti-inflammatory and analgesic effects of green tea (Camellia sinensis) in mice
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Evaluation of the anti-inflammatory and analgesic effects of green tea (Camellia sinensis) in mice

机译：绿茶（Camellia sinensis）对小鼠的抗炎和镇痛作用的评估

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PURPOSE: To evaluate the anti-inflammatory and analgesic effects of green tea (Camellia sinensis) in mice.METHODS:The anti-inflammatory effect of alcoholic extracts of green tea (AE) was evaluated in a cell migration assay with four groups of six Swiss mice receiving 0.07g/Kg or 0.14g/Kg EA (treatment groups), saline (negative control) or 10mg/Kg indomethacin (positive control) by gavage. One hour later 300 μg carrageen an was administered intraperitoneally or subcutaneously. The analgesic effect was evaluated using four groups of six animals receiving 0.07g/Kg or 0.14g/Kg EA, saline or 10mg/Kg indomethacin subcutaneously, followed 30 minutes later by 1% acetic acid.RESULTS: When administered subcutaneously at either dose (0.07g/Kg and 0.14g/Kg), AE inhibited carrageenan-induced cell migration (p0.05). However, when administered by gavage, only the latter (0.14 g/Kg) was efficient (p0.05). AE at both doses (0.07g/Kg and 0.14g/Kg) inhibited abdominal contortions (p0.05), but the effect was not dose-dependent.CONCLUSION:Green tea was shown to have analgesic and anti-inflammatory properties and may constitute a natural treatment option in chronic inflammatory disorders.
机译：目的：评估绿茶（Camellia sinensis）对小鼠的抗炎和镇痛作用。方法：在四组六只瑞士人的细胞迁移试验中，对绿茶（AE）的酒精提取物的抗炎作用进行了评估。通过管饲法接受0.07g / Kg或0.14g / Kg EA（治疗组），盐水（阴性对照）或10mg / Kg消炎痛（阳性对照）的小鼠。一小时后，腹膜内或皮下施用300μg角叉菜胶。使用六组动物的四组动物评估镇痛效果，每只动物皮下注射0.07g / Kg或0.14g / Kg EA，盐水或10mg / Kg消炎痛，随后30分钟后加入1％乙酸。 0.07g / Kg和0.14g / Kg），AE抑制了角叉菜胶诱导的细胞迁移（p <0.05）。但是，当通过管饲法给药时，只有后者（0.14 g / Kg）有效（p <0.05）。两种剂量（0.07g / Kg和0.14g / Kg）的AE均能抑制腹部扭曲（p <0.05），但该作用并非剂量依赖性。结论：绿茶具有镇痛和抗炎作用，可能构成慢性炎性疾病的自然治疗选择。

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