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首页> 外文期刊>ACS Omega >Review on the Ugi Multicomponent Reaction Mechanism and the Use of Fluorescent Derivatives as Functional Chromophores
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Review on the Ugi Multicomponent Reaction Mechanism and the Use of Fluorescent Derivatives as Functional Chromophores

机译：Ugi多组分反应机理及荧光衍生物作为功能发色团的研究进展

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In the present mini-review we discuss the findings, controversies, and gaps observed for the Ugi four-component reaction. The Ugi multicomponent reaction, performed by mixing an aldehyde, an amine, a carboxylic acid, and an isocyanide, is among the most important isocyanide-based multicomponent reactions (MCRs), allowing multiple bond formations (C–C and C–N) in a single synthetic step. The possibility of two reaction pathways and the little understood solvent effect over this transformation renders this reaction as one of the hardest challenges to overcome. The little knowledge of the mechanism of the Ugi MCR hinders the development of new and efficient chiral catalytic systems to further the application of the derivatives obtained by enantioselective versions. The asymmetric transformation is in this context a bigger challenge, and little is known about the mechanism of these few available versions. The new trend of functional chromophore synthesis by MCRs is also highlighted, and the few examples already disclosed in the literature exemplify the huge opportunity for investigation and creative ideas using the Ugi four-component reaction.
机译：在当前的小型审查中，我们讨论了Ugi四组分反应的发现，争议和差距。通过混合醛，胺，羧酸和异氰酸酯进行的Ugi多组分反应是最重要的基于异氰酸酯的多组分反应（MCR）之一，可以在反应中形成多个键（CC和C–N）。单个合成步骤。两条反应路径的可能性以及对该转化的了解甚少的溶剂效应使该反应成为最难克服的挑战之一。对Ugi MCR机理的了解甚少，阻碍了新的和有效的手性催化体系的发展，以进一步应用对映选择性形式获得的衍生物。在这种情况下，非对称转换是一个更大的挑战，对这几种可用版本的机制知之甚少。还强调了通过MCR合成功能性发色团的新趋势，并且文献中已经公开的几个例子证明了使用Ugi四组分反应进行研究和创新的巨大机会。

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