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首页> 外文期刊>ACS Omega >Anion Complexation Studies of 3-Nitrophenyl-Substituted Tripodal Thiourea Receptor: A Naked-Eye Detection of Sulfate via Fluoride Displacement Assay
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Anion Complexation Studies of 3-Nitrophenyl-Substituted Tripodal Thiourea Receptor: A Naked-Eye Detection of Sulfate via Fluoride Displacement Assay

机译：3-硝基苯基取代的三脚架硫脲受体的阴离子络合研究：氟化物置换法检测硫酸盐的裸眼

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摘要

A thiourea-based tripodal receptor L substituted with 3-nitrophenyl groups has been synthesized, and the binding affinity for a variety of anions has been studied by ~(1)H NMR titrations and nuclear Overhauser enhancement spectroscopy experiments in dimethyl sulfoxide-d _(6). As investigated by ~(1)H NMR titrations, the receptor binds an anion in a 1:1 binding mode, showing the highest binding and strong selectivity for sulfate anion. A competitive colorimetric assay in the presence of fluoride suggests that the sulfate is capable of displacing the bound fluoride, showing a sharp visible color change. The strong affinity of L for sulfate was further supported by UV–vis titrations and density functional theory (DFT) calculations. Time-dependent DFT calculations indicate that the fluoride complex possesses a different optical absorption spectrum (due to charge transfer between the fluoride and the surrounding ligand) than the sulfate complex, reflecting the observed colorimetric change in these two complexes. The receptor was further tested for its biocompatibility on primary human foreskin fibroblasts and HeLa cells, exhibiting an excellent cell viability up to 100 μM concentration.
机译：已合成了被3-硝基苯基取代的基于硫脲的三脚架受体bL，并已通过〜（1）H NMR滴定和核二甲基亚砜中的Overhauser增强光谱实验研究了对多种阴离子的结合亲和力。 d_（6）。如〜（1）H NMR滴定所研究的，受体以1：1结合模式结合阴离子，显示出最高的结合力和对硫酸根阴离子的强选择性。在氟化物存在下的竞争比色测定表明，硫酸盐能够取代结合的氟化物，显示出明显的可见颜色变化。 UV-vis滴定法和密度泛函理论（DFT）计算进一步支持了 L对硫酸盐的强亲和力。与时间有关的DFT计算表明，氟化物配合物与硫酸盐配合物相比具有不同的光吸收光谱（由于氟化物和周围配体之间的电荷转移），反映了这两种配合物中观察到的比色变化。对该受体在原代人包皮成纤维细胞和HeLa细胞上的生物相容性进行了进一步测试，显示出高达100μM浓度的优异细胞活力。

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