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首页> 外文期刊>African Journal of Biotechnology >Glucose and triglyceride lowering activity of Pterocarpus santaniloides leaf extracts against dexamethasone induced hyperlipidemia and insulin resistance in rats
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Glucose and triglyceride lowering activity of Pterocarpus santaniloides leaf extracts against dexamethasone induced hyperlipidemia and insulin resistance in rats

机译：紫檀叶片提取物的葡萄糖和甘油三酸酯降低大鼠地塞米松致高脂血症和胰岛素抵抗的活性

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The triglyceride and glucose lowering potential of the leaf extracts of?Pterocarpus santalinoides?was investigated in dexamethasone induced hyperlipidemia and insulin resistance in rats.?Acute toxicity test was performed according to standard methods. An oral glucose tolerance test was carried out in the presence of the extracts in normal rats. Then, graded doses of aqueous and methanol extracts of?P. santalinoides?(AEPS and MEPS) were administered orally to rats in four groups, respectively, after a 12 h fast followed by subcutaneous administration of dexamethasone (10 mg/kg body wt). Rats in a fifth group received saline (5 ml/kg p.o) followed by dexamethasone (10 mg/kg body wt s.c) and served as positive control while a sixth group served as normal control. The period of extract and dexamethasone administration was 10 days.?Acute toxicity test showed that the extract had an oral LD50?> 5000 mg/kg in rats. Graded?doses of? aqueous and methanol extracts of?P. santalinoides?to glucose loaded normal rats?resulted in significant lowering of blood glucose concentration which started at 90 min post-glucose load when compared with the 60 mine (peak) sample (p < 0.001) and also when compared with the negative control value at 90 min (p < 0.001).Administration of dexamethasone to fasted rats for 10 days resulted in hyperlipidemia and insulin resistance??evidenced?by?the?significant increase in mean glucose level (194.50 ± 9.87 mg/dl) and triglyceride level (268.75 ± 21.54 mg/dl) in the positive control when compared with the?normal?control with mean glucose and triglyceride concentrations of 64.00 ± 3.44 mg/dl and 100.00 ± 15.54 mg, respectively (p < 0.01; p < 0.001). Graded doses of the AEPS?and MEPS significantly antagonized dexamethasone induced hyperlipidemia and insulin resistance in rats when compared with the positive control (p < 0.001) and thenormal?control, respectively (p < 0.05). The antagonistic potency of AEPS was dose dependent while that of the MEPS was not. The leaf extracts of?P. santalinoidespossess triglyceride and glucose lowering properties in dexamethasone induced hyperlipidemia and insulin resistance and could be of therapeutic value in the management of metabolic syndrome.
机译：在地塞米松诱发的大鼠高脂血症和胰岛素抵抗中，研究了紫檀叶提取物的甘油三酸酯和降低葡萄糖的能力。按照标准方法进行了急性毒性试验。在正常大鼠中在提取物存在下进行口服葡萄糖耐量试验。然后，分级剂量的βP水和甲醇提取物。禁食12小时后，分别对四组大鼠口服檀香碱类药物（AEPS和MEPS），然后皮下注射地塞米松（体重10 mg / kg）。第五组大鼠接受生理盐水（5 ml / kg p.o），然后接受地塞米松（10 mg / kg体重皮下注射），作为阳性对照，第六组作为正常对照。提取物和地塞米松的给药时间为10天。急性毒性试验表明，提取物在大鼠中的口服LD50≥5000mg / kg。分级？剂量？ P的水和甲醇提取物。檀香碱对葡萄糖负荷正常大鼠的血糖水平显着降低，与60矿样（峰值）样品相比，葡萄糖负荷后90分钟开始（p <0.001），并且与阴性对照相比，血糖浓度显着降低。 90分钟（p <0.001）。禁食10天的地塞米松导致高脂血症和胰岛素抵抗，这通过平均葡萄糖水平（194.50±9.87 mg / dl）和甘油三酸酯水平（268.75）的显着增加来证明。与正常对照组相比，阳性对照的平均葡萄糖和甘油三酸酯浓度分别为64.00±3.44 mg / dl和100.00±15.54 mg（±21.54 mg / dl）（p <0.01; p <0.001）。与阳性对照（p <0.001）和正常对照（p <0.05）相比，AEPS？和MEPS的分级剂量显着拮抗地塞米松诱导的大鼠高脂血症和胰岛素抵抗。 AEPS的拮抗效力与剂量有关，而MEPS的拮抗效力与剂量无关。 P的叶提取物。檀香烷在地塞米松诱发的高脂血症和胰岛素抵抗中具有甘油三酸酯和葡萄糖降低的特性，在代谢综合征的治疗中可能具有治疗价值。

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