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首页> 外文期刊>African Journal of Biotechnology >Butyrylcholinesterase activity in Nigerian type 2 diabetics with and without metabolic syndrome
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Butyrylcholinesterase activity in Nigerian type 2 diabetics with and without metabolic syndrome

机译：患有和不患有代谢综合征的尼日利亚2型糖尿病患者的丁酰胆碱酯酶活性

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Type 2 diabetes mellitus is a chronic progressive disease typified by a loss of glycaemic control over time as the insulin secreting pancreatic β-cells lose their ability to compensate for the prevailing levels of insulin sensitivity. Several abnormalities are associated with diabetes and metabolic syndrome. Butyrylcholinesterase activity in diabetes and metabolic syndrome is generally under reported.? Blood samples and demographic data were obtained from one hundred and five patients presenting at Specialist Hospital Sokoto, Nigeria. These were screened for type 2 diabetes according to the guidelines of the American Diabetes Association. Based on anthropometric indices and clinical data, patients were stratified into to 4 groups: Control (n = 44), type 2 diabetics with metabolic syndrome (n = 14), obese type 2 diabetics without metabolic syndrome (n = 21) and non-obese type 2 diabetics without metabolic syndrome (n = 26). Butyrylcholinesterase was assayed by kinetic and colorimetric method, other biochemical and clinical parameters were according to standard methods. Type 2 diabetics with or without metabolic syndrome have significantly higher activity of butyrylcholinesterase than control group. The higher activity of the enzyme may have been influenced by hyperglycemia, obesity and metabolic syndrome through enhanced transcription or catalytic mechanism of the enzyme or both. Butyrylcholinesterase activity may serve as marker to predict the development of type 2 diabetes and or metabolic syndrome.
机译：2型糖尿病是一种慢性进行性疾病，其特征是随着时间的流逝，血糖控制失控，因为分泌胰岛素的胰腺β细胞失去了补偿普遍存在的胰岛素敏感性水平的能力。一些异常与糖尿病和代谢综合征有关。糖尿病和代谢综合症中的丁酰胆碱酯酶活性普遍报道不足。血液样本和人口统计学数据是从尼日利亚索科托专科医院的115名患者中获得的。根据美国糖尿病协会的指南对这些患者进行了2型糖尿病筛查。根据人体测量学指标和临床数据，将患者分为4组：对照组（n = 44），患有代谢综合征的2型糖尿病患者（n = 14），没有代谢综合征的肥胖2型糖尿病患者（n = 21）和非肥胖的2型糖尿病患者。无代谢综合征的肥胖2型糖尿病患者（n = 26）。用动力学和比色法测定丁酰胆碱酯酶，其他生化和临床参数均按标准方法测定。患有或不患有代谢综合征的2型糖尿病患者的丁酰胆碱酯酶活性明显高于对照组。该酶的较高活性可能是由于该酶的增强转录或催化机理或两者引起的高血糖症，肥胖症和代谢综合征的影响。丁酰胆碱酯酶活性可作为预测2型糖尿病和/或代谢综合征发展的标志。

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