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Influence of technology in genetic epidemiology

机译：技术对遗传流行病学的影响

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Genetic epidemiology is the study of genetic factors and their influence on health and disease. Traditionally, these studies have been based on familial aggregation, segregation, or linkage analysis, mainly allowing the study of monogenic disorders. Advances in biotechnology have made techniques such as genome-wide association studies and next-generation sequencing possible, allowing more complex studies. In addition to the completion of large consortia projects, such as the Human Genome Project, ENCODE, and the 1000 Genome Project, these techniques make it possible to explain a higher proportion of the heritability in polygenic disorders compared to previous techniques. Here, we provide an overview of approaches to genetic epidemiology and how technological improvements have influenced experimentation in this area. These improvements have led genetic epidemiology to unprecedented advances, being excellent tools for understanding the genetic variability underlying complex phenotypes.
机译：遗传流行病学是对遗传因素及其对健康和疾病影响的研究。传统上，这些研究基于家族聚集，分离或连锁分析，主要用于研究单基因疾病。生物技术的进步使诸如全基因组关联研究和下一代测序的技术成为可能，从而允许进行更复杂的研究。除了完成大型联合体项目（如人类基因组计划，ENCODE和1000基因组计划）外，与以前的技术相比，这些技术还可以解释多基因疾病中遗传力的较高比例。在这里，我们概述了遗传流行病学的方法以及技术进步如何影响了该领域的实验。这些改进使遗传流行病学取得了空前的进步，成为了解复杂表型背后遗传变异性的绝佳工具。

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