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首页> 外文期刊>American Journal of Epidemiology >Genetic Epidemiology and Public Health: The Evolution From Theory to Technology
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Genetic Epidemiology and Public Health: The Evolution From Theory to Technology

机译:遗传流行病学与公共卫生:从理论到技术的演变

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摘要

Genetic epidemiology represents a hybrid of epidemiologic designs and statistical models that explicitly consider both genetic and environmental risk factors for disease. It is a relatively new field in public health; the term was first coined only 35 years ago. In this short time, the field has been through a major evolution, changing from a field driven by theory, without the technology for genetic measurement or computational capacity to apply much of the designs and methods developed, to a field driven by rapidly expanding technology in genomic measurement and computational analyses while epidemiologic theory struggles to keep up. In this commentary, we describe 4 different eras of genetic epidemiology, spanning this evolution from theory to technology, what we have learned, what we have added to the broader field of public health, and what remains to be done.
机译:遗传流行病学是流行病学设计和统计模型的混合体,明确考虑了疾病的遗传和环境风险因素。这是公共卫生领域中一个相对较新的领域。这个词最早是在35年前提出的。在短时间内,该领域经历了一次重大的发展,从理论驱动的领域转变为没有基因测量或计算能力的技术来应用许多已开发的设计和方法,而在此领域迅速发展。基因组测量和计算分析,而流行病学理论难以跟上。在这篇评论中,我们描述了遗传流行病学的四个不同时代,涵盖了从理论到技术的演变,我们所学到的知识,我们为更广泛的公共卫生领域所添加的内容以及尚待完成的工作。

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