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Neural stem cell derived tumourigenesis

机译:神经干细胞源性肿瘤发生

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In the developing Drosophila CNS, two pools of neural stem cells, the symmetrically dividing progenitors in the neuroepithelium (NE) and the asymmetrically dividing neuroblasts (NBs) generate the majority of the neurons that make up the adult central nervous system (CNS). The generation of a correct sized brain depends on maintaining the fine balance between neural stem cell self-renewal and differentiation, which are regulated by cell-intrinsic and cell-extrinsic cues. In this review, we will discuss our current understanding of how self-renewal and differentiation are regulated in the two neural stem cell pools, and the consequences of the deregulation of these processes.
机译:在发育中的果蝇中枢神经系统中,神经干细胞的两个池,神经上皮细胞中的对称分裂祖细胞和不对称细胞的成神经细胞(NBs)生成了构成成人中枢神经系统(CNS)的大部分神经元。正确大小的大脑的生成取决于维持神经干细胞自我更新与分化之间的良好平衡,而神经干细胞自我更新与分化受细胞内源性和细胞外源性信号的调节。在这篇综述中,我们将讨论我们目前对两个神经干细胞池中如何调节自我更新和分化以及这些过程失控的后果的理解。

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