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首页> 外文期刊>American Journal of Drug Discovery and Development >Undeniable Pharmacological Potentials of Quinazoline Motifs in Therapeutic Medicine
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Undeniable Pharmacological Potentials of Quinazoline Motifs in Therapeutic Medicine

机译：喹唑啉基体在治疗医学中不可否认的药理潜力

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Despite the advances in technology and understanding of biological systems, drug discovery is still a lengthy, expensive, difficult and inefficient process owing to low rate of new therapeutic discovery. Among the numerous N-heterocyclic scaffolds, quinazoline core structural frameworks have received considerable attention because they form a privileged class of pharmacophores with diverse spectrum of therapeutic potential. Various conventional synthetic approaches methodologies for quinazoline synthesis by various synthetic chemists were explored in this review wherein their bases for structural validation were expatiated using analytical data and spectroscopic means such as FT-IR, UV-Visible, 1H- and 13C-NMR as well as mass spectra. Quinazoline derivatives are among the most useful heterocyclic compounds from both synthetic and medicinal chemistry aspects. They are considered as important precursors for the synthesis of various physiologically significant and pharmacologically utilized molecules. This present study unveils quinazoline core as a multifunctional nucleus which serves as a resourceful toolbox of information for synthetic modifications of old existing candidates in order to tackle drug resistance bottlenecks in therapeutic medicine. Based on diverse bioactivities and pharmacological potentials were explored, quinozaline motifs were concluded to be arsenals of warfare against infectious diseases in therapeutics. Hence, quinazolines might pave way to new drug discovery for fighting infectious diseases and increase researchers’ choice of quinazoline as excellent candidates for future drug design.
机译：尽管技术和对生物系统的理解有了进步，但是由于新的治疗发现率低，药物发现仍然是一个漫长，昂贵，困难和低效的过程。在众多的N-杂环支架中，喹唑啉核心结构框架受到了相当大的关注，因为它们形成了具有多种治疗潜力的特权类药效团。这篇综述探讨了各种合成化学家合成喹唑啉的各种常规合成方法，其中使用了分析数据和光谱学手段（例如FT-IR，UV-Visible，1H-和13C-NMR）阐明了其结构验证的基础。质谱。从合成化学和药物化学两个方面来看，喹唑啉衍生物都是最有用的杂环化合物。它们被认为是合成各种具有生理意义和药理学用途的分子的重要前体。本研究揭示了喹唑啉核心作为多功能核，可作为信息资源的工具箱，用于对旧的现有候选药物进行合成修饰，以解决治疗药物中的耐药性瓶颈。基于各种生物活性和药理潜力进行了探索，喹za啉基序被认为是治疗学中针对传染病的战争武器库。因此，喹唑啉可能为抗击传染病的新药开发铺平道路，并增加研究人员对喹唑啉作为未来药物设计的优秀候选者的选择。

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