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首页> 外文期刊>Antibiotics >A Novel Organo-Selenium Bandage that Inhibits Biofilm Development in a Wound by Gram-Positive and Gram-Negative Wound Pathogens
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A Novel Organo-Selenium Bandage that Inhibits Biofilm Development in a Wound by Gram-Positive and Gram-Negative Wound Pathogens

机译：一种新型有机硒绷带，可抑制革兰氏阳性和革兰氏阴性伤口病原体在伤口中的生物膜形成。

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Biofilm formation in wounds is a serious problem which inhibits proper wound healing. One possible contributor to biofilm formation in a wound is the bacteria growing within the overlying bandage. To test this mechanism, we used bandages that contained a coating of organo-selenium that was covalently attached to the bandage. We tested the ability of this coating to kill bacteria on the bandage and in the underlying tissue. The bandage material was tested with both lab strains and clinical isolates of Staphylococcus aureus, Pseudomonas aeruginosa and Staphylococcus epidermidis. It was found that the organo-selenium coated bandage showed inhibition, of biofilm formation on the bandage in vitro (7–8 logs), with all the different bacteria tested, at selenium concentrations in the coating of less than 1.0%. These coatings were found to remain stable for over one month in aqueous solution, 15 min in boiling water, and over 6 years at room temperature. The bandages were also tested on a mouse wound model where the bacteria were injected between the bandage and the wound. Not only did the selenium bandage inhibit biofilm formation in the bandage, but it also inhibited biofilm formation in the wound tissue. Since selenium does not leave the bandage, this would appear to support the idea that a major player in wound biofilm formation is bacteria which grows in the overlying bandage.
机译：伤口中生物膜的形成是一个严重的问题，阻碍了伤口的正常愈合。伤口中生物膜形成的一种可能原因是细菌在覆盖绷带内生长。为了测试这种机制，我们使用了包含有机硒涂层的绷带，该涂层共价附于绷带。我们测试了这种涂层杀死绷带和下层组织中细菌的能力。用实验室菌株和金黄色葡萄球菌，铜绿假单胞菌和表皮葡萄球菌的临床分离株测试了绷带材料。研究发现，在测试的所有不同细菌中，有机硒包被的绷带在包被中的硒浓度低于1.0％时，对生物绷带的体外生物膜形成具有抑制作用（7-8 log）。发现这些涂料在水溶液中可保持稳定超过一个月，在沸水中保持15分钟，在室温下保持超过6年。还在小鼠伤口模型上测试了绷带，其中将细菌注射在绷带和伤口之间。硒绷带不仅抑制了绷带中生物膜的形成，而且还抑制了伤口组织中生物膜的形成。由于硒不会离开绷带，因此这似乎支持以下观点：伤口生物膜形成的主要参与者是在上方绷带中生长的细菌。

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