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首页> 外文期刊>Advancements in Life Sciences >Identification and Antimicrobial Susceptibility Profile of Bacterial Pathogens Isolated From Wound Infections in a Teaching Hospital, Peshawar, Pakistan
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Identification and Antimicrobial Susceptibility Profile of Bacterial Pathogens Isolated From Wound Infections in a Teaching Hospital, Peshawar, Pakistan

机译：在巴基斯坦白沙瓦的一家教学医院从伤口感染中分离出的细菌病原体的鉴定和抗菌药物敏感性分析

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Background: The resistance profile of bacteria causing wound infections may vary from time to time in a given geographical location. The key objective of this study was to determine the prevalent aerobic and or facultative anaerobic bacterial types and their antibiogram to commonly prescribed antibiotics. Methods: Pus, drainage or wound swabs from various body parts of 200 patients were aseptically collected from Khyber Teaching Hospital (KTH) and processed by standard microbiological techniques for identification of bacterial isolates and later antimicrobial susceptibility profile was determined as per Clinical and Laboratory Standard Institute (CLSI) guidelines by using Kirby-Bauer method. Results: Out of 200 clinical wound specimens processed, Staphylococcus aureus was the most common bacterial pathogen isolated (n=100, 50%), followed by Escherichia coli (n=45, 22.5%), Pseudomonas aeruginosa (n=35, 17.5%), Enterobacter species (n=14, 7%), Proteus species (n=5, 2.5%) and Morganella species (n=1, 0.5%). Staphylococcus aureus (n=100) showed highest resistance to amoxicillin (82%), followed by ofloxacin (80%), sparfloxacin (78%), ciprofloxacin (71%), levofloxacin (46%) and Gentamicin (34%). Out of 100 S. aureus isolates methicillin and vancomycin resistance was found to be in 1.5 and 2% of the isolates, respectively. Among Gram negative isolates (n=100) the vast majority were resistant to augmentin, followed by cephalosporins, quinolones and almost fairly susceptible to carbapenems, cefoperazone + sulbactam and aminoglycosides. Conclusion: There is a need for judicious use of antibiotics in clinical setup. The periodic monitoring of bacterial pathogens and their susceptibility profile is very helpful in understanding the resistance phenotypes in a given area which ultimately help physicians in selecting suitable empirical therapy.
机译：背景：在给定的地理位置，引起伤口感染的细菌的抵抗力可能会不时变化。这项研究的主要目的是确定常见的需氧和/或兼性厌氧细菌类型及其对常用处方抗生素的抗菌谱。方法：从开伯尔教学医院（KTH）无菌采集200名患者各部位的脓液，引流液或伤口拭子，并通过标准微生物学技术进行处理，以鉴定细菌分离物，然后根据临床和实验室标准协会确定其抗菌药敏性（CLSI）准则，请使用Kirby-Bauer方法。结果：在处理的200个临床伤口标本中，金黄色葡萄球菌是最常见的细菌病原体（n = 100，50％），其次是大肠杆菌（n = 45，22.5％），铜绿假单胞菌（n = 35，17.5％） ），肠杆菌属（n = 14，7％），变形杆菌属（n = 5，2.5％）和摩根氏菌（n = 1，0.5％）。金黄色葡萄球菌（n = 100）对阿莫西林的耐药性最高（82％），其次是氧氟沙星（80％），司帕沙星（78％），环丙沙星（71％），左氧氟沙星（46％）和庆大霉素（34％）。在100株金黄色葡萄球菌中，发现甲氧西林和万古霉素的耐药性分别为1.5％和2％。在革兰氏阴性分离株（n = 100）中，绝大多数对增强素具有抗性，其次是头孢菌素，喹诺酮类药物，几乎对碳青霉烯类，头孢哌酮+舒巴坦和氨基糖苷类药物相当敏感。结论：在临床环境中需要明智地使用抗生素。细菌病原体及其敏感性分布图的定期监测对于了解给定区域的耐药表型非常有帮助，最终有助于医生选择合适的经验疗法。

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