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首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >MicroRNA-133b expression associates with clinicopathological features and prognosis in glioma
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MicroRNA-133b expression associates with clinicopathological features and prognosis in glioma

机译：MicroRNA-133b表达与脑胶质瘤的临床病理特征和预后有关

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Abstract Background: Recently, microRNA-133b (miR-133b) dysregulation has been shown to play a key role in several human cancers, as well as glioma. In this study, we aimed to investigate the clinical significance and prognostic value of miR-133b in glioma. Methods: Real-time quantitative PCR was employed to measure the expression level of miR-133b in tissues. Survival analysis was carried out by using the log-rank test and Kaplan–Meier method. Prognostic factors for overall survival were identified by univariate and multivariate analyses using the Cox proportional hazards regression model. Results: The expression level of miR-133b was significantly lower in glioma tissues compared with matched non-cancerous brain tissues (p?p?p?p?=?.03). Conclusions: The current investigation demonstrated that miR-133b level is useful for predicting the prognosis of patients with glioma.
机译：摘要背景：最近，已显示microRNA-133b（miR-133b）失调在几种人类癌症以及神经胶质瘤中起关键作用。在这项研究中，我们旨在调查miR-133b在神经胶质瘤中的临床意义和预后价值。方法：采用实时定量PCR检测miR-133b在组织中的表达水平。使用对数秩检验和Kaplan-Meier方法进行生存分析。使用Cox比例风险回归模型通过单因素和多因素分析确定总体生存的预后因素。结果：与匹配的非癌性脑组织相比，神经胶质瘤组织中miR-133b的表达水平显着降低（p？p？p？p？= ?. 03）。结论：目前的研究表明，miR-133b水平可用于预测神经胶质瘤患者的预后。

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