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首页> 外文期刊>Annals of Indian Academy of Neurology >Autologous hematopoietic stem cell transplantation in progressive severe multiple sclerosis
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Autologous hematopoietic stem cell transplantation in progressive severe multiple sclerosis

机译：进行性严重多发性硬化症的自体造血干细胞移植

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Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system (CNS), which is disabling and majorly involves younger population. Various available treatments in forms of immunomodulation are not very effective; however, stem cell transplantation seems to be promising in recent literature. The current case report is a novel evidence for autologous hematopoietic stem cell transplantation (HSCT) in progressive MS. Case Summary: A 33 year old male with secondary progressive MS (SPMS), after being failed and/or intolerance to standard approved interferon (IFN) and mitoxantrone therapy, autologous HSCT was administered. At 2years of post-stem cell transplantation follow-up, he has remained stable with some improvement in functional status (Expanded Disability Status Scale (EDSS) reduced by 1.5), with no relapse, no treatment related complications, and no fresh magnetic resonance imaging (MRI) lesions. Conclusion: Autologous stem cell transplantation may be beneficial in progressive forms of MS, but needs to be tested in well-designed randomized trial.
机译：多发性硬化症（MS）是中枢神经系统（CNS）的一种慢性炎症性疾病，正在致残，主要涉及年轻人口。各种可用的免疫调节形式的治疗方法都不是很有效。然而，干细胞移植在最近的文献中似乎很有希望。本病例报告是进行性MS中自体造血干细胞移植（HSCT）的新证据。病例摘要：一名33岁男性，继发进行性MS（SPMS），失败和/或对标准批准的干扰素（IFN）和米托蒽醌治疗不耐受后，施行自体HSCT。在干细胞移植后2年的随访中，他保持稳定，功能状态有所改善（扩展残疾状态量表（EDSS）降低了1.5），无复发，无治疗相关并发症，也没有新鲜的磁共振成像（MRI）病变。结论：自体干细胞移植在进展性MS中可能是有益的，但需要在设计良好的随机试验中进行测试。

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