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首页> 外文期刊>Australian Journal of Crop Science >Physiological comparison between mulberry (Morus alba L.) leaves diet and artificial diet on growth development as well as antibiotic therapeutic response of silkworms
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Physiological comparison between mulberry (Morus alba L.) leaves diet and artificial diet on growth development as well as antibiotic therapeutic response of silkworms

机译：桑叶饮食和人工饮食对桑蚕生长发育及抗生素治疗反应的生理比较

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Silkworm has been proposed recently as an animal model for the study of therapeutic effects of drug candidates. Little is known regarding the factors influencing the physiology of the silkworm, and this might become the major effect of the therapeutic result interpretation. In the present study, the effect of a diet of mulberry leaves as compared to an artificial diet on Thai silkworm growth development as well as the antibiotic therapeutic responses of bacterial infected silkworms is explored. The silkworms fed with mulberry leaves as well as those with artificial diets were weighed and the numbers of survival were counted. The mulberry leaves- fed silkworms (MFS) showed faster growth rate (0.2 g body weight day?1) than the artificial diet-fed silkworms (AFS). The MFS exhibited bigger body size and greater body weight than the AFS. It was found that the median lethal dose (LD50) of Staphylococcus aureus cells needed to kill 1-g body weight silkworms was 108 cells ml?1 for both MFS and AFS. However, the median effective dose (ED50) of the antibiotics (ampicillin, ceftriaxone, cephalexin, and gentamicin) for AFS was two times higher than those for MFS. The results indicate that some elements in mulberry leaf affect the therapeutic effect of the antibiotics in the silkworm model. This study suggests that high attention on silkworm diet should be paid to the research relevant to drug therapeutic evaluation using silkworms as an animal model.
机译：近年来，作为研究候选药物的治疗作用的动物模型，提出了蚕。关于影响蚕生理的因素知之甚少，这可能成为解释治疗结果的主要作用。在本研究中，探索了与人工饮食相比，桑叶饮食对泰国蚕生长发育的影响以及细菌感染的蚕的抗生素治疗反应。称重饲喂桑叶的蚕和人工饮食的蚕，并计算存活数。桑叶饲喂的蚕（MFS）比人工饮食饲喂的蚕（AFS）显示出更快的生长速度（0.2 g体重日-1）。 MFS比AFS具有更大的体型和更大的体重。结果发现，杀死Ms和AFS所需的杀死1 g体重蚕的金黄色葡萄球菌细胞的中值致死剂量（LD50）为108细胞ml？1。但是，AFS的抗生素（氨苄青霉素，头孢曲松，头孢氨苄和庆大霉素）的中位有效剂量（ED50）是MFS的中位数有效剂量的两倍。结果表明，桑叶中的某些元素会影响家蚕模型中抗生素的治疗效果。这项研究表明，应将对蚕食的研究高度重视，以蚕为动物模型进行与药物治疗评估有关的研究。

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