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Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters in male rats

机译:山楂提取物对雄性大鼠糖尿病性记忆障碍及血清生化指标的影响

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This study was undertaken to investigate the Crataegus extract (CE) e? ;ects on diabetes-induced memory deficit in passive avoidance learning (PAL), blood glucose, and lipid profile panel. Male Wistar rats were divided into five groups:Control(CTRL);Diabetic(DM); andDiabetic animals treatedwith three doses of CE (100, 300 and 1000?mg/kg) (DM?+?CE). Streptozotocin (STZ)-induced diabetic rats (50?mg/kg, ip) were orally administrated with CE once a day for 2 weeks. After 2 weeks, PAL task was used to evaluate the passive avoidance learning and memory. At the end of experiment, the level of plasma glucose, triglycerides (TG), cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were determined. Our results showed that the step-through latency (STLr) in diabetic animals was less than the control group (P?=?0.0009). Crataegus (300?mg) increased STLr in diabetic animals (P?=?0.0418). Diabetic animals spent more time in the dark compartment (TDC) (P?=?0.0009). Crataegus (300 and 1000?mg) decreased TDC in diabetic animals (P?=?0.0175). Crataegus (100 and 300?mg) decreased blood glucose in diabetic animals (P??0.05). CE (1000?mg) increased HDL in diabetic animals (P?
机译:进行这项研究以调查山楂提取物(CE)的含量。 ;对被动回避学习(PAL),血糖和血脂谱方面的糖尿病诱发的记忆缺陷的影响。将雄性Wistar大鼠分为五组:对照组(CTRL);糖尿病组(DM);对照组(DM)。糖尿病动物用三种剂量的CE(100、300和1000?mg / kg)(DM ++ CE)处理。每天一次口服链脲佐菌素(STZ)诱导的糖尿病大鼠(50?mg / kg,腹膜内),连续2周。 2周后,PAL任务用于评估被动回避学习和记忆。在实验结束时,确定了血浆葡萄糖,甘油三酸酯(TG),胆固醇,低密度脂蛋白(LDL)和高密度脂蛋白(HDL)的水平。我们的结果表明,糖尿病动物的逐步潜伏期(STLr)小于对照组(P≥0.0009)。糖尿病动物的Crataegus(300?mg)增加了STLr(P?=?0.0418)。糖尿病动物在暗室(TDC)中花费了更多的时间(P≥0.0009)。 Crataegus(300和1000?mg)降低了糖尿病动物的TDC(P?=?0.0175)。 Crataegus(100和300?mg)降低了糖尿病动物的血糖(P 0.001)。与对照组相比,糖尿病动物的TG和胆固醇浓度升高(P <0.05)。 CE(100和300?mg)降低了糖尿病动物的胆固醇浓度(P 0.001)。实验组中LDL的情况无显着性差异(P≥0.05)。 CE(1000mg)增加了糖尿病动物的HDL(P <0.05)。我们的研究结果表明,CE具有降血脂和降糖作用,并能改善STZ诱导的糖尿病患者的记忆力。

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