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首页> 外文期刊>Indian Journal of Medical Microbiology >Serum hepatitis B surface antigen levels correlate with high serum HBV DNA levels in patients with chronic hepatitis B: A cross-sectional study
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Serum hepatitis B surface antigen levels correlate with high serum HBV DNA levels in patients with chronic hepatitis B: A cross-sectional study

机译：慢性乙型肝炎患者血清乙肝表面抗原水平与血清​​HBV DNA高水平相关

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Purpose : The hallmark of chronic hepatitis B (CHB) infection is the presence of hepatitis B surface antigen (HBsAg) positivity for at least 6 months. Recently, serum levels of HBsAg have been compared with serum HBV DNA as a surrogate marker to monitor CHB patients. However, data correlating these two markers are scarce. Hence, the present study was done to correlate HBV DNA with HBsAg in CHB patients. Materials and Methods: Consecutive patients of CHB were included. HBV DNA was measured by real-time polymerase chain reaction (PCR). Serum HBsAg was measured by Architect HBsAg. Results: Of the 198 patients enrolled, 166 fulfilled the inclusion criteria (mean age 43 ± 14 years, 87% males) and the median HBV DNA was 1.7 × 10 3 (range 6.0-1.1 × 10 8 ) IU/ml. Median HBsAg was 8.7 × 10 3 (range 5.0-3.2 × 10 5) IU/ml. Overall correlation between HBV DNA and HBsAg was weak but significant (Spearman ρ = 0.443, P 0.01). Correlation in HBe antigen-positive group was better (ρ = 0.402, P 0.01) in comparison to HBe antigen-negative group (ρ = 0.193 P = 0.05). Good correlation existed in treatment-naïve group (ρ = 0.538, P 0.01) .Correlation was regardless of normal or raised alanine transaminase (ALT). Eighty (48%) patients had high HBV DNA (≥2000 IU/ml). Correlation in high DNA group was significant (P 0.01). The best cut-off of HBsAg for diagnosing high DNA is 3.36 ×10 3 IU/ml. Conclusions: Serum HBsAg correlates with HBV DNA in CHB patients, especially in high serum HBV DNA, HBe antigen-positive and treatment-naïve group. HBsAg levels can be used for predicting high serum HBV DNA levels.
机译：目的：慢性乙型肝炎（CHB）感染的特征是存在至少6个月的乙型肝炎表面抗原（HBsAg）阳性。最近，已经将血清HBsAg水平与血清​​HBV DNA作为监测CHB患者的替代指标进行了比较。但是，与这两个标记相关的数据很少。因此，本研究完成了将CHB患者的HBV DNA与HBsAg相关联的研究。材料和方法：包括连续性CHB患者。 HBV DNA通过实时聚合酶链反应（PCR）进行测量。血清HBsAg由建筑师HBsAg测量。结果：纳入的198例患者中，有166例符合纳入标准（平均年龄43±14岁，男性87％），中位HBV DNA为1.7×10 3 （范围6.0-1.1×10 < sup> 8 ）IU / ml。 HBsAg中位数为8.7×10 3 （范围5.0-3.2×10 5 ）IU / ml。 HBV DNA与HBsAg之间的总体相关性较弱但很显着（Spearmanρ= 0.443，P <0.01）。与HBe抗原阴性组（ρ= 0.193 P = 0.05）相比，HBe抗原阳性组的相关性更好（ρ= 0.402，P <0.01）。初治组之间存在良好的相关性（ρ= 0.538，P <0.01）。相关性与正常或升高的丙氨酸转氨酶（ALT）无关。八十（48％）例患者的HBV DNA高（≥2000 IU / ml）。高DNA组的相关性显着（P <0.01）。诊断高DNA的最佳HBsAg临界值是3.36×10 3 IU / ml。结论：CHB患者的血清HBsAg与HBV DNA相关，尤其是高血清HBV DNA，HBe抗原阳性和未接受过治疗的人群。 HBsAg水平可用于预测血清HBV DNA高水平。

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