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首页> 外文期刊>Indian Journal of Pathology and Microbiology >Decoy cells in the urine cytology of a renal transplant recipient: An immunohistochemical study
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Decoy cells in the urine cytology of a renal transplant recipient: An immunohistochemical study

机译：肾移植受者尿液细胞学中的诱饵细胞：免疫组织化学研究

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摘要

Human polyoma virus causes renal dysfunction and graft loss as a result of tubulo-interstial nephritis in renal transplant recipients after reactivation of latent virus in renal epithelium. The infected cells in the urinary sediments are characterized by large homogenous inclusions, which may cause diagnostic error in urine cytology. The epithelial cells with polyoma viral inclusions in urine cytology specimens are termed Decoy cells to caution pathologists not to misdiagnose these cells as cancer cells. We present a case of polyoma viral changes detected the first time in our laboratory in the urine of a 46year old male who underwent renal transplantation six months back and followed by immunotherapy. Urine cytological examination showed decoy cells and subsequently revealed on histopathology. Immunoperoxidase staining for SV-40 LT antigen (LT ag), expression of proliferating cell nuclear antigen (PCNA), p53 and Rb genes were also studied in the tissue sections for further observation. The expression of SV40 LT ag was negative, while PCNA showed strong positivity; p53 and Rb were expressed moderately in the nuclei of cells in the tubules. The report of a case of decoy cells in the urine of a patient with renal transplantation focuses the importance of cytologic analysis of urine as a diagnostic tool for screening renal transplant recipients at risk of polyoma viral infection.
机译：人多瘤病毒在肾上皮中的潜伏病毒重新激活后，会因肾移植受者的肾小管间质性肾炎而导致肾功能不全和移植物丢失。尿沉渣中受感染的细胞具有较大的均质内含物，可能会导致尿液细胞学诊断错误。尿液细胞学样本中具有多瘤病毒包涵体的上皮细胞被称为诱饵细胞，以提醒病理学家不要将这些细胞误诊为癌细胞。我们提供了一个多瘤病毒变化的病例，该病毒变化是在我们的实验室中首次检测到的一位46岁男性的尿液，该男性在六个月前接受了肾脏移植，然后进行了免疫治疗。尿细胞学检查显示诱饵细胞，随后在组织病理学上发现。还在组织切片中研究了SV-40 LT抗原（LT ag）的免疫过氧化物酶染色，增殖细胞核抗原（PCNA），p53和Rb基因的表达，以作进一步观察。 SV40 LT ag的表达为阴性，而PCNA阳性。 p53和Rb在小管中的细胞核中适度表达。肾移植患者尿液中诱饵细胞病例的报告强调了尿液细胞学分析作为筛查有多瘤病毒感染风险的肾移植受者的诊断工具的重要性。

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