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Regulation of intestinal Th17 and Treg cells by gut microbiota

机译：肠道菌群对肠道Th17和Treg细胞的调节

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Dysbiosis, an imbalance in the gut microbiota composition, is significantly associated with inflammatory bowel disease and other immune disorders. Dysbiosis can dysregulate immune system, compromise mucosal barrier integrity, and perpetuate chronic inflammation. Therefore, gut microbiota manipulation could be potentially used for treating various inflammatory diseases. Various intestinal bacteria differentially regulate the development and function of different immune cell populations. In particular, bacterial species falling within clusters VI and XIVa of the class Clostridia affect the generation and function of mucosal regulatory T cells, whereas segmented filamentous bacteria are the strong inducers for T helper 17 cells. This review discusses how the components of the gut microbiota affect the host immune system and disease susceptibility.
机译：消化不良是肠道菌群组成的失衡，与炎症性肠病和其他免疫疾病显着相关。营养不良会导致免疫系统失调，损害粘膜屏障完整性，并使慢性炎症永久化。因此，肠道菌群操纵可潜在地用于治疗各种炎性疾病。各种肠道细菌差异地调节不同免疫细胞群的发育和功能。特别地，落入梭菌属的簇VI和XIVA中的细菌种类影响粘膜调节性T细胞的产生和功能，而分段的丝状细菌是T辅助细胞17的强诱导剂。这篇评论讨论了肠道菌群的组成部分如何影响宿主的免疫系统和疾病易感性。

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