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首页> 外文期刊>International Journal of Environmental Research and Public Health >The Effect of Bisphenol A on Puberty: A Critical Review of the Medical Literature
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The Effect of Bisphenol A on Puberty: A Critical Review of the Medical Literature

机译：双酚A对青春期的影响：医学文献的批判性回顾。

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Many scientific studies have revealed a trend towards an earlier onset of puberty and have disclosed an increasing number of children that display precocious puberty. As an explanation, some authors have considered the global socio-economic improvement across different populations, and other authors have considered the action of endocrine disrupting chemicals (EDCs). Among these, bisphenol A (BPA), an aromatic compound largely used worldwide as a precursor of some plastics and chemical additives, is well known for its molecular oestrogen-like and obesogenic actions. We reviewed the medical literature of the previous 20 years that examined associations between BPA exposure and the age of puberty in humans, considering only those referring to clinical or epidemiological data. Of 19 studies, only 7 showed a correlation between BPA and puberty. In particular, the possible disruptive role of BPA on puberty may be seen in those with central precocious puberty or isolated premature breast development aged 2 months to 4 years old, even if the mechanism is undefined. Some studies also found a close relationship between urinary BPA, body weight, and early puberty, which can be explained by the obesogenic effect of BPA itself. The currently available data do not allow establishment of a clear role for BPA in pubertal development because of the conflicting results among all clinical and epidemiological studies examined. Further research is needed to fully understand the potential role of exposure to EDCs and their adverse endocrine health outcomes.
机译：许多科学研究揭示了青春期早发的趋势，并揭示了越来越多的表现出性早熟的儿童。作为一种解释，一些作者考虑了不同人群在全球范围内的社会经济改善，而另一些作者则考虑了内分泌干扰物（EDC）的作用。其中，双酚A（BPA）是一种芳香族化合物，在世界范围内被广泛用作某些塑料和化学添加剂的前体，以其类似分子雌激素和致肥胖作用而闻名。我们回顾了过去20年的医学文献，该文献研究了BPA暴露与人类青春期之间的关联，仅考虑了那些涉及临床或流行病学数据的文献。在19项研究中，只有7项显示BPA与青春期之间存在相关性。尤其是，BPA对青春期可能具有破坏性作用，即使其机制尚不确定，也可能在年龄在2个月至4岁之间的中枢性性早熟或孤立的过早的乳房发育中发现。一些研究还发现，尿液BPA，体重和青春期早期之间有密切的关系，这可以由BPA本身的致肥胖作用来解释。由于所检查的所有临床和流行病学研究结果相互矛盾，因此目前无法获得的数据无法明确BPA在青春期发育中的作用。需要进一步研究以充分了解暴露于EDCs的潜在作用及其不利的内分泌健康结果。

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