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首页> 外文期刊>International Journal of Environmental Research and Public Health >Dietary Nickel Chloride Induces Oxidative Intestinal Damage in Broilers
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Dietary Nickel Chloride Induces Oxidative Intestinal Damage in Broilers

机译：日粮氯化镍诱导肉鸡氧化性肠损伤

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摘要

The purpose of this study was to investigate the oxidative damage induced by dietary nickel chloride (NiCl2) in the intestinal mucosa of different parts of the intestine of broilers, including duodenum, jejunum and ileum. A total of 240 one-day-old broilers were divided into four groups and fed on a corn-soybean basal diet as control diet or the same basal diet supplemented with 300, 600 or 900 mg/kg NiCl2 during a 42-day experimental period. The results showed that the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), and the ability to inhibit hydroxy radical and glutathione (GSH) content were significantly (p < 0.05 or p < 0.01) decreased in the 300, 600 and 900 mg/kg groups in comparison with those of the control group. In contrast, malondialdehyde (MDA) content was significantly (p < 0.05 or p < 0.01) higher in the 300, 600 and 900 mg/kg groups than that in the control group. It was concluded that dietary NiCl2 in excess of 300 mg/kg could cause oxidative damage in the intestinal mucosa in broilers, which finally impaired the intestinal functions including absorptive function and mucosal immune function. The oxidative damage might be a main mechanism on the effects of NiCl2 on the intestinal health of broilers.
机译：这项研究的目的是调查日粮氯化镍（NiCl2）对肉鸡肠道不同部位（包括十二指肠，空肠和回肠）肠道粘膜的氧化损伤。在42天的实验期内，总共将240只1日龄的肉仔鸡分为4组，以玉米-大豆基础日粮作为对照日粮或补充300、600或900 mg / kg NiCl2的同一基础日粮喂养。结果表明，超氧化物歧化酶（SOD），过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GSH-Px）的活性以及抑制羟自由基和谷胱甘肽（GSH）含量的能力均显着（p <0.05或p <0.01）与对照组相比，在300、600和900 mg / kg组降低了。相反，在300、600和900 mg / kg组中，丙二醛（MDA）含量明显高于对照组（p <0.05或p <0.01）。结论是日粮NiCl2含量超过300 mg / kg可能会导致肉鸡肠道粘膜氧化损伤，最终损害肠道功能，包括吸收功能和粘膜免疫功能。氧化损伤可能是NiCl2对肉鸡肠道健康影响的主要机制。

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