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首页> 外文期刊>International Journal of Environmental Research and Public Health >Pyrethroid Pesticide Metabolite in Urine and Microelements in Hair of Children Affected by Autism Spectrum Disorders: A Preliminary Investigation
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Pyrethroid Pesticide Metabolite in Urine and Microelements in Hair of Children Affected by Autism Spectrum Disorders: A Preliminary Investigation

机译：自闭症谱系障碍患儿尿液和头发中微量元素的拟除虫菊酯类农药代谢产物的初步调查

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The number of children affected by Autism Spectrum Disorders (ASD) is dramatically increasing as well as the studies aimed at understanding the risk factors associated with the development of ASD. Since the etiology of ASD is partly genetic and partly environmental, factors ( i.e. , heavy metals, pesticides) as well as lifestyle seem to have a key role in the development of the disease. ASD and Control (CTR) children, aged 5–12 years, were compared. Gas chromatography coupled with trap mass detector was used to measure the level of 3-PBA, the main pyrethroid metabolite in urine in a group of ASD patients, while optical emission spectrometry analysis was employed to estimate the level of metals and microelements in hair in a different group of ASD children. The presence of 3-PBA in urine seems to be independent of age in ASD children, while a positive correlation between 3-PBA and age was observed in the control group of the same age range. Urine concentration of 3-BPA in ASD children had higher values than in the control group, which were marginally significant ( p = 0.054). Mg results were significantly decreased in ASD with respect to controls, while V, S, Zn, and Ca/Mg were marginally increased, without reaching statistical significance. Results of Principal Component (PC) analysis of metals and microelements in hair were not associated with either age or health status. In conclusion, 3-PBA in urine and Mg in hair were changed in ASD children relative to control ones.
机译：自闭症谱系障碍（ASD）所影响的儿童人数正在急剧增加，而旨在了解与ASD的发展相关的危险因素的研究也在迅速增加。由于ASD的病因部分是遗传的，部分是环境的，因此因素（即重金属，农药）以及生活方式似乎在该疾病的发展中具有关键作用。比较了5-12岁的ASD和对照（CTR）儿童。气相色谱结合阱质量检测器测量了一组ASD患者尿液中主要的拟除虫菊酯3-PBA的水平，而光发射光谱分析法则用于评估头发中金属和微量元素的水平。不同组的ASD儿童。尿液中3-PBA的存在似乎与ASD儿童的年龄无关，而在相同年龄范围的对照组中，观察到3-PBA与年龄之间呈正相关。 ASD儿童中3-BPA的尿液浓度值比对照组中的值高，这在边缘上是显着的（p = 0.054）。相对于对照，ASD中的镁结果显着降低，而V，S，Zn和Ca / Mg略有增加，但未达到统计学意义。头发中金属和微量元素的主成分（PC）分析结果与年龄或健康状况均无关。总之，与对照组相比，ASD儿童尿液中的3-PBA和头发中的Mg发生了变化。

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