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首页> 外文期刊>International Journal of Environmental Research and Public Health >Pyrethroid Pesticide Metabolite in Urine and Microelements in Hair of Children Affected by Autism Spectrum Disorders: A Preliminary Investigation
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Pyrethroid Pesticide Metabolite in Urine and Microelements in Hair of Children Affected by Autism Spectrum Disorders: A Preliminary Investigation

机译：尿嘧啶农药代谢物在受自闭症谱系影响的儿童的头发中尿液和微量元素：初步调查

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The number of children affected by Autism Spectrum Disorders (ASD) is dramatically increasing as well as the studies aimed at understanding the risk factors associated with the development of ASD. Since the etiology of ASD is partly genetic and partly environmental, factors (i.e., heavy metals, pesticides) as well as lifestyle seem to have a key role in the development of the disease. ASD and Control (CTR) children, aged 5–12 years, were compared. Gas chromatography coupled with trap mass detector was used to measure the level of 3-PBA, the main pyrethroid metabolite in urine in a group of ASD patients, while optical emission spectrometry analysis was employed to estimate the level of metals and microelements in hair in a different group of ASD children. The presence of 3-PBA in urine seems to be independent of age in ASD children, while a positive correlation between 3-PBA and age was observed in the control group of the same age range. Urine concentration of 3-BPA in ASD children had higher values than in the control group, which were marginally significant (p = 0.054). Mg results were significantly decreased in ASD with respect to controls, while V, S, Zn, and Ca/Mg were marginally increased, without reaching statistical significance. Results of Principal Component (PC) analysis of metals and microelements in hair were not associated with either age or health status. In conclusion, 3-PBA in urine and Mg in hair were changed in ASD children relative to control ones.
机译：受自闭症谱系障碍（ASD）影响的儿童的数量显着增加以及旨在了解与ASD发展相关的风险因素的研究。由于ASD的病因是部分遗传和部分环境，因素（即重金属，杀虫剂）以及生活方式似乎在疾病的发展中具有关键作用。比较ASD和Control（CTR）儿童5-12岁。与陷阱质量检测器相结合的气相色谱法用于测量一组ASD患者尿液中尿嘧啶的主要拟除虫菊酯代谢物水平，而使用光学发射光谱分析以估算a中的头发中的金属和微量元素水平。不同群体ASD儿童。尿液3-PBA的存在似乎与ASD儿童的年龄无关，而在同一年龄范围的对照组中观察到3-PBA和年龄之间的正相关。在ASD儿童3-BPA的尿液浓度具有比对照组更高的值，这是略微显着的（P = 0.054）。对于对照而言，MG结果显着降低，而V，S，Zn和Ca / Mg在没有达到统计显着性的情况下略微增加。主要成分（PC）的原因分析头发中的金属和微量元素与年龄或健康状况无关。总之，在ASD儿童相对于对照组中，尿液中尿液中的3-PBA和镁的镁在尿液中变化。

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