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首页> 外文期刊>International Journal of Implant Dentistry >Vertical ridge augmentation using a porous composite of uncalcined hydroxyapatite and poly-DL-lactide enriched with types 1 and 3 collagen
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Vertical ridge augmentation using a porous composite of uncalcined hydroxyapatite and poly-DL-lactide enriched with types 1 and 3 collagen

机译：使用未煅烧的羟基磷灰石与富含1型和3型胶原的聚DL-丙交酯的多孔复合材料进行垂直隆脊

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Abstract BackgroundPrevious studies have shown that porous composite blocks containing uncalcined hydroxyapatite (u-HA; 70?wt%) with a scaffold of poly-DL-lactide (PDLLA, 30?wt%) are biodegradable, encourage appropriate bone formation, and are suitable for use as a bone substitute in vertical ridge augmentation. The present study aimed to accelerate osteogenesis in vertical ridge formation by adding types 1 and 3 collagen to the u-HA/PDLLA blocks and assessing the effect.Material and methodsThe bone substitute in the present study comprised porous composite blocks of u-HA (70?wt%) with a PDLLA (27–29?wt%) scaffold and enriched with types 1 and 3 collagen (1.7 ~?3.4?wt%). The control blocks were composed of u-HA (70?wt%) and PDLLA (30?wt%). The materials were formed into 8-mm diameter, 2-mm high discs and implanted onto the cranial bones of six rabbits. The animals were sacrificed 4?weeks after implantation, and histological and histomorphometrical analyses were performed to quantitatively evaluate newly formed bone.ResultsNew bone formation occurred with both block types, showing direct contact with the original bone. Mean?±?standard deviation bone formation was significantly greater in the experimental blocks (25.6%?±?4.8%) than in the control blocks (17.0%?±?4.7%).ConclusionsHistological and histomorphometrical observations indicated that new bone was formed with both block types. The u-HA/PDLLA block with types 1 and 3 collagen is a more promising candidate for vertical ridge augmentation than the u-HA/PDLLA alone block.
机译：抽象背景以前的研究表明，含有未煅烧的羟基磷灰石（u-HA; 70？wt％）和聚DL-丙交酯（PDLLA，30？wt％）支架的多孔复合材料块是可生物降解的，可促进适当的骨形成，并且适合用作垂直骨增强的骨替代物。本研究旨在通过向u-HA / PDLLA嵌段中添加1型和3型胶原蛋白并评估其效果来加速垂直脊形成中的成骨作用。材料和方法本研究中的骨替代物包括u-HA的多孔复合材料嵌段（70重量％）带有PDLLA（27-29重量％）支架，并富含1型和3型胶原蛋白（1.7〜3.4重量％）。对照块由u-HA（70％（重量））和PDLLA（30％（重量））组成。这些材料被制成直径8毫米，高2毫米的椎间盘，并植入到六只兔子的颅骨上。植入后4周将动物处死，并进行组织学和组织形态分析，以定量评估新形成的骨骼。结果两种块状均发生新的骨骼形成，显示出与原始骨骼的直接接触。实验组（25.6％±±4.8％）的平均Δ±标准偏差骨形成显着大于对照组（17.0％±±4.7％）。结论组织学和组织形态学观察表明，新骨形成于两种块类型。与单独的u-HA / PDLLA嵌段相比，具有1型和3型胶原的u-HA / PDLLA嵌段是更有希望的垂直增生候选物。

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