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首页> 外文期刊>International Journal of Chemistry >Isolation and Structure Elucidation of Bioactive Compounds Chemical as Inhibitors of the Enzyme ?-Glucosidase Raru Bark Ethanol Extract (Vatica pauciflora Blume)
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Isolation and Structure Elucidation of Bioactive Compounds Chemical as Inhibitors of the Enzyme ?-Glucosidase Raru Bark Ethanol Extract (Vatica pauciflora Blume)

机译：生物活性化合物作为酶β-葡萄糖苷酶的抑制剂的分离和结构解析Raru树皮乙醇提取物（Vatica pauciflora Blume）

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摘要

Inhibitory compound of ?-glucosidase bioactivity was isolated from ethanol extract of the stem bark of raru (Vatica pauciflora Blume) which, is a wild plant that grows in Tapanuli state in Indonesia.The ethanol extract of the stem bark of raru was partitioned and was chromatographed on columns with stationare fase silica gel 60 mesh F254 (0.063 mm-0.200 mm). The ethanol extract of isolates showed the enzyme ?-glucosidase inhibitor IC50 of 93.46. The next step is the determination of the chemical structure of the Ultraviolet–visible spectroscopy (UV Vis); FT-IR (Fourier Transform Infrared spectroscopy), NMR (Nuclear Magnetic Resonance) namely COSY, Heteronuclear Multiple-Quantum Correlation (HMQC); and Heteronuclear Multiple-Bond Correlation (HMBC). It found of compounds consist of two of methoxy, one of aromatic, and one of carbonil compounds. The isolat is a 3,4,9,Trihidroxy-2-(hydroxymethyl)-8-10-dimethoxy-2-3-4atetrahydropyrano(3,2-c)isochromen-6(10bH)-one acording to International Union of Pure and Applied Chemistry (IUPAC).
机译：从印度尼西亚塔帕努利州生长的野生植物拉鲁（Vatica pauciflora Blume）的茎皮乙醇提取物中分离出抑制活性的β-葡萄糖苷酶化合物。使用固定式硅胶60目F254（0.063 mm-0.200 mm）色谱柱进行色谱分离。分离物的乙醇提取物显示β-葡糖苷酶抑制剂的IC50为93.46。下一步是确定紫外-可见光谱（UV Vis）的化学结构。 FT-IR（傅里叶变换红外光谱法），NMR（核磁共振），即COSY，异核多量子相关性（HMQC）;和异核多键相关（HMBC）。发现由二甲氧基，一种芳香族和一种羰基化合物组成的化合物。 isolat是3,4,9，Trihidroxy-2-（羟甲基）-8-10-dimethoxy-2-3-4atetrahydropyrano（3,2-c）isochromen-6（10bH）-根据国际纯净联合会和应用化学（IUPAC）。

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