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首页> 外文期刊>International journal of molecular imaging >Functional Imaging of Pheochromocytoma with68Ga-DOTATOC and68C-HED in a Genetically Defined Rat Model of Multiple Endocrine Neoplasia
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Functional Imaging of Pheochromocytoma with68Ga-DOTATOC and68C-HED in a Genetically Defined Rat Model of Multiple Endocrine Neoplasia

机译：68Ga-DOTATOC和68C-HED在多发性内分泌肿瘤的大鼠模型中对嗜铬细胞瘤的功能成像

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Rats affected by the MENX multitumor syndrome develop pheochromocytoma (100%). Pheochromocytomas are uncommon tumors and animal models are scarce, hence theinterest in MENX rats to identify and preclinically evaluate novel targeted therapies. Aprerequisite for such studies is a sensitive and noninvasive detection of MENXassociatedpheochromocytoma. We performed positron emission tomography (PET) todetermine whether rat pheochromocytomas are detected by tracers used in clinicalpractice, such as 68Ga-DOTATOC (somatostatin analogue) or11C-Hydroxyephedrine(HED), a norepinephrine analogue. We analyzed four affected and three unaffected rats. The PET scan findings were correlated to histopathology and immunophenotype of thetumors, their proliferative index, and the expression of genes coding for somatostatinreceptors or the norepinephrine transporter. We observed that mean 68Ga-DOTATOCstandard uptake value (SUV) in adrenals of affected animals was 23.3 ± 3.9, significantlyhigher than in control rats (15.4 ± 7.9;P=.03). The increase in mean tumor-to-liver ratioof11C-HED in the MENX-affected animals (1.6 ± 0.5) compared to controls (0.7 ± 0.1)was even more significant (P=.0016). In a unique animal model, functional imagingdepicting two pathways important in pheochromocytoma biology discriminated affectedanimals from controls, thus providing the basis for future preclinical work with MENXrats.
机译：受到MENX多肿瘤综合征影响的大鼠会出现嗜铬细胞瘤（100％）。嗜铬细胞瘤是罕见的肿瘤，并且缺乏动物模型，因此对MENX大鼠感兴趣的是鉴定和临床前评估新型靶向疗法。进行此类研究的先决条件是敏感，无创地检测MENX相关嗜铬细胞瘤。我们进行了正电子发射断层扫描（PET），以确定是否通过临床实践中使用的示踪剂（例如68Ga-DOTATOC（生长抑素类似物）或11C-羟麻黄碱（去甲肾上腺素类似物））检测到大鼠嗜铬细胞瘤。我们分析了四只患病大鼠和三只未患病大鼠。 PET扫描的发现与肿瘤的组织病理学和免疫表型，它们的增殖指数以及编码生长抑素受体或去甲肾上腺素转运蛋白的基因的表达有关。我们观察到，患病动物肾上腺的平均68Ga-DOTATOC标准摄取值（SUV）为23.3±3.9，显着高于对照组大鼠（15.4±7.9; P = .03）。与对照组（0.7±0.1）相比，在MENX感染的动物中11C-HED的平均肿瘤/肝脏比率增加（1.6±0.5）更为显着（P = .0016）。在独特的动物模型中，描述嗜铬细胞瘤生物学中重要的两条途径的功能成像将受影响的动物与对照区分开来，从而为将来与MENXrats进行临床前研究奠定了基础。

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