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首页> 外文期刊>International Journal of Phytopharmacy >A Novel and Rapid Method for Formulation and Simultaneous Evaluation of Polyherbal Tablet for Hypothyroidism by HPTLC
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A Novel and Rapid Method for Formulation and Simultaneous Evaluation of Polyherbal Tablet for Hypothyroidism by HPTLC

机译：HPTLC新型快速制备甲状腺功能减退症的多草药片并同时进行评估的方法

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Herbal Pharma industry is rapidly expanding its demand in national as well as international market. Due to lack of pharmaceutical and analytical validation of herbal products, quality of herbal products differs from batch to batch. Pharmaceutical and analytical validation can be achieved, if the herbal products are evaluated and analyzed using both herbal as well as modern techniques of standardization; in process and after preparation of finished product. A fast, rapid, sensitive and stability indicating high-performance thin-layer chromatographic (HPTLC) method is developed and validated for qualitative estimation of Patol ( Trichosanthes dioica ), Indrajav ( Holarrhena antidysenterica ), Kanchnar ( Bauhinia variegate ), Shigru ( Moringa oleifera ), Varun Chal ( Crataeva nurvala ) and Trikatu ( Piper longum, Piper nigrum and Zingiber officinalis ) simultaneously in pharmaceutical herbal formulation (Tablet) . Chromatographic separation of the herbs is performed on aluminium backed plates coated with silica gel 60F254 as the stationary phase and the solvent system consisted of n-Hexane: n-Butanol: Toluene: Ethyl Acetate (5:5:3:2). Samples were applied with Linomat V under nitrogen gas flow. The densitometric analysis was performed CAMAG TLC scanner 4 at 300nm. All the three samples prepared by this method shows identical characteristics and analytical parameters does not show significant difference. Also the observations of analytical study show similarity to those parameters which are already set in API for this drug.
机译：草药制药行业正在迅速扩展其在国内以及国际市场上的需求。由于缺乏草药产品的药物和分析验证，因此草药产品的质量因批次而异。如果使用草药以及现代标准化技术对草药产品进行评估和分析，则可以实现药物和分析验证;在生产过程中以及准备成品之后。建立了一种快速，快速，灵敏和稳定的指示性高性能薄层色谱（HPTLC）方法，并已定性评估了Patol（Trichosanthes dioica），Indrajav（Holarrhena antidysenterica），Kanchnar（Bauhinia variegate），Shigru（Moringa oleifera） ），Varun Chal（Cretaeva nurvala）和Trikatu（Piper longum，Piper nigrum和Zingiber officinalis）同时在药物草药制剂（平板电脑）中使用。草药色谱分离是在涂有硅胶60F254作为固定相的铝背板上进行的，溶剂系统由正己烷：正丁醇：甲苯：乙酸乙酯（5：5：3：2）组成。在氮气流下用Linomat V施加样品。在300nm下进行CAMAG TLC扫描仪4的光密度分析。用此方法制备的所有三个样品均显示出相同的特性，而分析参数没有显示出明显差异。分析研究的观察结果也显示与该药物的API中已设置的那些参数相似。

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