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首页> 外文期刊>International Journal of Pharmaceutical Sciences and Research >ANTIDIARRHOEAL AND ANALGESIC ACTIVITY OF BARKS OF MEDICINAL PLANT CAESALPINIA PULCHERRIMA
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ANTIDIARRHOEAL AND ANALGESIC ACTIVITY OF BARKS OF MEDICINAL PLANT CAESALPINIA PULCHERRIMA

机译：药用植物洋槐皮的树皮的抗菌和止痛活性

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摘要

The ethanolic extract of barks of Caesalpinia pulcherrima (Family- Caesalpiniaceae) was evaluated for anti-diarrhoeal and analgesic activities in animal models. The crude ethanolic extract of Caesalpinia pulcherrima showed considerable anti-diarrhoeal activity on castor oil induced diarrhoea in mice and it increased mean latent period and decreased the frequency of defecation significantly (P<0.001) at the oral dose of 500 mg/kg body weight comparable to the standard drug Loperamide at the dose of 50 mg/kg of body weight. The extract of barks also produced significant (P<0.001) writhing inhibition in acetic acid induced writhing in mice at the oral dose of 500 mg/kg body weight where writhing inhibition for the extract of barks was 47.11%, which was comparable to the standard drug Diclofenac sodium at the dose of 25 mg/kg of body weight.
机译：评价了Caesalpinia pulcherrima（家族-Caesalpiniaceae）的树皮的乙醇提取物在动物模型中的止泻和镇痛活性。 es草乙醇提取物对蓖麻油引起的腹泻具有显着的止泻作用，在口服剂量为500 mg / kg体重时，其平均潜伏期延长且排便频率显着降低（P <0.001）以50毫克/公斤体重的剂量服用标准药物洛哌丁胺。在口服剂量为500 mg / kg体重的乙酸中，树皮提取物在乙酸诱导的小鼠扭体中也产生明显的（P <0.001）扭体抑制作用，其中对树皮提取物的扭体抑制率为47.11％，与标准品相当药物双氯芬酸钠的剂量为25 mg / kg体重。

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