...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Pharmacological Research >Antiplasmodial effects of the aqueous ethanolic seed extract of Ziziphus mauritiana against Plasmodium berghei in Swiss albino mice
【24h】

Antiplasmodial effects of the aqueous ethanolic seed extract of Ziziphus mauritiana against Plasmodium berghei in Swiss albino mice

机译：枣的含水乙醇种子提取物对瑞士白化病小鼠的伯氏疟原虫的抗血浆作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ziziphus mauritiana is a fruit tree used traditionally since long back for wound healing, immunepotentiator, asthma, sedative, stomachic, styptic, as tonic etc. The present study determines the antiplasmodial effect of aqueous ethanolic seed extract against Chloroquine sensitive Plasmodium berghei berghei nk65 infection in Swiss albino mice. Based upon the acute toxicity data three different doses (100, 200, 400 mg/kg body weight) of the plant extract was chosen to study the blood schizonticidal activity in early infection and in established infection and was compared with chloroquine. The Prophylactic activity was also assessed and compared with pyrimethamine. No mortality was observed in acute toxicity study however, above the dose of 1000 mg/kg animals showed the lethargic behaviour. In early infection, and in established infection the doses (100-400 mg/kg b.wt) was found to cause significant ( P <0.001) suppression of infection in a dose dependent manner as compared to control. Although, the activity was lower than standard chloroquine. Similarly, the extract at all the doses caused the suppression in repository activity but was lower than pyrimethamine. The mean survival time was also increased in mice by 14 and 17 days at the doses of 200 and 400 mg/kg respectively, whereas the control group sustained only for 7 days. Thus, the seed extract showed the effectiveness against plasmodium infection.
机译：Ziziphus mauritiana是一棵果树，从长久以来就一直用于伤口愈合，免疫增强剂，哮喘，镇静剂，胃药，止血药，补药等。本研究确定了含水乙醇种子提取物对氯喹敏感的伯氏疟原虫berghei nk65感染的抗血浆作用。瑞士白化病小鼠。根据急性毒性数据，选择了三种不同剂量（100、200、400 mg / kg体重）的植物提取物，以研究早期感染和确定感染中的血裂杀虫活性，并与氯喹进行了比较。还评估了预防活性并将其与乙胺嘧啶进行比较。在急性毒性研究中未观察到死亡率，但是，超过1000 mg / kg的剂量动物表现出嗜睡行为。在早期感染中和在确定的感染中，与对照相比，发现剂量（100-400 mg / kg b.wt）以剂量依赖性方式引起显着（P <0.001）抑制感染。虽然，该活性低于标准的氯喹。类似地，所有剂量的提取物都引起了贮库活性的抑制，但低于乙胺嘧啶。在200和400 mg / kg的剂量下，小鼠的平均存活时间也分别增加了14天和17天，而对照组仅持续7天。因此，种子提取物显示出抗疟原虫感染的功效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号