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首页> 外文期刊>International Journal of Reproduction, Contraception, Obstetrics and Gynecology >A study of thyroid profile in cases of primary infertility attending a tertiary care hospital of south India
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A study of thyroid profile in cases of primary infertility attending a tertiary care hospital of south India

机译：在印度南部一家三级护理医院就读的原发性不孕患者甲状腺状况的研究

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Background: Infertility is a rising major problem affecting more than 50 million couples globally every year. Endocrine as well as immune system abnormalities can impair the fertility. Most of the studies globally indicated association of infertility with multiple factors like stress, luteal phase defects, structural and functional reproductive disturbances. Many infertile women with thyroid dysfunction had associated hyperprolactinemia with increases TSH in ovulatory dysfunction. The aim of the present study was to determine the association of hypo and hyperthyroidism with infertility among cases of primary infertility in women. Methods: A cross sectional study was conducted among the patients attending the infertility clinic for the first time. The study was approved by the institutional ethical committee and the study was carried as per the guidelines of the ethical committee. The serum levels of T3, T4 and TSH were estimated and Prolactin in cases where necessary by Chemiluminiscence immunoassay. The data was analyzed by using the unpaired “t” test. A ‘p’ value 0.05 was considered significant. Results: 285 cases were enrolled and majority (38.6%) was in 31-34 age groups with mean age of 24.2± 1.6 years. 30.53% were found with thyroid dysfunction. Majority (16.49%) were found with subclinical hypothyroid, followed in order by primary hypothyroid (9.82%), subclinical hyperthyroid (2.11%), primary hyperthyroid (1.05%), secondary hypothyroid (0.70%) and secondary hyperthyroid (0.35%). Conclusions: To conclude, thyroid dysfunction is a common cause of infertility and can be easily managed by correcting the levels of thyroid hormones. Present study suggests that thyroid replacement therapy in subclinical hypothyroidism at an early stage is justified in infertile women. Borderline variations in TSH levels should not be ignored in infertile women who are otherwise asymptomatic for subclinical hypothyroidism. Hence for better management of cases of primary infertility studies with large sample size and long term follow up are required to validate and justify the variation in TSH and prolactin levels.
机译：背景：不育是一个日益严重的主要问题，每年影响全球超过5000万对夫妇。内分泌以及免疫系统异常会损害生育能力。全球大多数研究表明，不孕症与多种因素有关，例如压力，黄体期缺陷，结构和功能性生殖障碍。许多患有甲状腺功能障碍的不育妇女与高泌乳素血症相关，排卵功能障碍中TSH升高。本研究的目的是确定女性原发性不育病例中甲状腺功能低下和甲状腺功能亢进与不育的关系。方法：首次在不育诊所就诊的患者中进行横断面研究。该研究得到机构伦理委员会的批准，并按照伦理委员会的指南进行。在必要的情况下通过化学发光免疫测定法估计了血清T3，T4和TSH水平和催乳激素水平。通过使用不成对的“ t”检验分析数据。小于0.05的“ p”值被认为是有意义的。结果：招募了285例病例，其中大多数（38.6％）位于31-34岁年龄段，平均年龄为24.2±1.6岁。 30.53％被发现有甲状腺功能障碍。亚临床甲状腺功能减退者占多数（16.49％），其次为原发性甲状腺功能减退（9.82％），亚临床甲状腺功能亢进（2.11％），原发性甲状腺功能亢进（1.05％），继发性甲状腺功能减退（0.70％）和继发性甲状腺功能亢进（0.35％）。结论：总而言之，甲状腺功能障碍是不孕症的常见原因，可以通过校正甲状腺激素水平轻松解决。目前的研究表明，在亚临床甲状腺功能减退症的早期，甲状腺替代疗法在不育妇女中是合理的。在不患有亚临床甲状腺功能减退症的不育妇女中，不应忽略TSH水平的临界变化。因此，为了更好地管理原发性不孕症病例，需要进行大样本量和长期随访，以验证和证明TSH和催乳素水平的变化。

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