• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Investigative Genetics >Genetic variation and population structure of Sudanese populations as indicated by 15 Identifiler sequence-tagged repeat (STR) loci
【24h】

Genetic variation and population structure of Sudanese populations as indicated by 15 Identifiler sequence-tagged repeat (STR) loci

机译：由15个Identifiler序列标签重复（STR）位点表明的苏丹种群的遗传变异和种群结构

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background There is substantial ethnic, cultural and linguistic diversity among the people living in east Africa, Sudan and the Nile Valley. The region around the Nile Valley has a long history of succession of different groups, coupled with demographic and migration events, potentially leading to genetic structure among humans in the region. Result We report the genotypes of the 15 Identifiler microsatellite markers for 498 individuals from 18 Sudanese populations representing different ethnic and linguistic groups. The combined power of exclusion (PE) was 0.9999981, and the combined match probability was 1 in 7.4 × 1017. The genotype data from the Sudanese populations was combined with previously published genotype data from Egypt, Somalia and the Karamoja population from Uganda. The Somali population was found to be genetically distinct from the other northeast African populations. Individuals from northern Sudan clustered together with those from Egypt, and individuals from southern Sudan clustered with those from the Karamoja population. The similarity of the Nubian and Egyptian populations suggest that migration, potentially bidirectional, occurred along the Nile river Valley, which is consistent with the historical evidence for long-term interactions between Egypt and Nubia. Conclusion We show that despite the levels of population structure in Sudan, standard forensic summary statistics are robust tools for personal identification and parentage analysis in Sudan. Although some patterns of population structure can be revealed with 15 microsatellites, a much larger set of genetic markers is needed to detect fine-scale population structure in east Africa and the Nile Valley.
机译：背景信息生活在东非，苏丹和尼罗河谷的人们之间存在着很大的种族，文化和语言多样性。尼罗河谷周围的地区拥有不同族群的悠久历史，再加上人口和移民事件，有可能导致该地区人类之间的遗传结构。结果我们报告了来自不同民族和语言群体的18个苏丹人口中498个人的15个Identifiler微卫星标记的基因型。排除总和（PE）为0.9999981，合并匹配概率为7.4×10 17 中的1。将苏丹人群的基因型数据与埃及，索马里和乌干达的Karamoja人群先前发布的基因型数据相结合。发现索马里人口在遗传上不同于其他东北非洲人口。苏丹北部的人与埃及的人聚在一起，苏丹南部的人与Karamoja人口的人聚在一起。努比亚人和埃及人的相似之处表明，沿着尼罗河河谷发生的迁移可能是双向的，这与埃及和努比亚人之间长期互动的历史证据是一致的。结论我们表明，尽管苏丹的人口结构水平很高，但标准的法医摘要统计数据仍是苏丹进行个人识别和父母身份分析的强大工具。尽管可以用15个微卫星揭示某些种群结构模式，但是需要大量的遗传标记来检测东非和尼罗河谷地区的小规模种群结构。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号