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Cugini's syndrome: its clinical history and diagnosis

机译：库吉尼综合征：其临床病史和诊断

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INTRODUCTION: This article deals with the description and diagnosis of a new nosographic syndrome, which received the eponym of "Cugini's syndrome" by the name of the Author who discovered its clinical picture. This syndrome is characterized by the binomial: "minimal target organ damage associated to monitoring prehypertension". CLINICAL HISTORY AND DIAGNOSIS: Between the years 1997 and 2002, the Author published a series of investigations regarding some office normotensives who inexplicably showed incipient signs of target organ damage (TOD). Investigated via ambulatory (A) blood (B) pressure (P) monitoring (M), these subjects were surprisingly found not to be hypertensive. Neverthless, the office normotensives with TOD exibited the daily mean level of their systolic (S) and diastolic (D) BP (DML SBP/DBP) significantly more elevated as compared to true normotensives. Because of these ABPM findings, the Author realized that the investigated subjects were false normotensives whose TOD was associated with a monitoring prehypertension (ABPM-diagnosable prehypertension alias monitoring prehypertension alias masked prehypertension). The year after the last Cugini's investigation, the INC-7 Reports introduced the term: "prehypertension" in its classification of arterial hypertension, as an office sphygmomanometric condition in between office normotension and office hypertension. The ABPM cut-off upper limits for a differential diagnosis between monitoring normotension, prehypertension and hypertension are reported, as calculated by the Author in its collection of ABPMs. The eponym of "Cugini's syndrome" was assigned in 2007 and confirmed in 2009. CONCLUSIVE REMARKS: The monitoring prehypertension is a further condition of discrepancy between office sphygmomanometry and ABPM, as per a masked prehypertension, whose diagnosis has to be immediately diagnosed, for preventing the onset of a TOD. There are reported the present investigations dealing with the possible need for an early antihypertensive treatment of prehypertension. A pharmacological treatment seems to be especially justified in the presence of a Cugini's syndrome.
机译：引言：本文介绍了一种新的鼻科综合症的描述和诊断，该症候群以发现其临床症状的作者的名字命名为“库吉尼综合症”。该综合征的特征是二项式：“与监测高血压前期相关的最小靶器官损害”。临床历史和诊断：在1997年至2002年之间，作者发表了一系列关于一些办公室血压正常的研究，这些血压莫名其妙地显示出靶器官损害（TOD）的初期迹象。通过动态（A）血液（B）压力（P）监测（M）进行了调查，令人惊讶地发现这些受试者并非高血压。不管怎样，与正常血压相比，TOD的办公室血压正常者其收缩压（S）和舒张压（D）BP（DML SBP / DBP）的每日平均水平明显升高。由于这些ABPM的发现，作者意识到被调查的对象是假的正常血压者，其TOD与监测性高血压相关（ABPM可诊断性高血压前兆别名监测高血压前兆别名掩盖了高血压前期）。在上次库吉尼人的调查后一年，INC-7报告在动脉高血压的分类中引入了“高血压前期”一词，作为介于办公室血压和办公室高血压之间的办公室血压计。根据作者在其ABPM集合中计算的结果，报告了在监测血压正常，高血压前期和高血压之间进行鉴别诊断的ABPM临界上限。 “库吉尼综合症”的别名于2007年分配，并于2009年得到确认。结论：监测血压过高是办公室血压计和ABPM之间存在差异的另一种情况，根据掩盖的血压过高，其诊断必须立即诊断，以预防TOD的发作。据报道，目前的调查涉及对高血压前期的早期抗高血压治疗的可能需求。在存在库吉尼综合症的情况下，药物治疗似乎特别合理。

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