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首页> 外文期刊>Lancet Neurology >Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis.
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Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis.

机译：提示多发性硬化症的临床孤立综合征，第一部分：自然史，发病机制，诊断和预后。

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In 85% of young adults with multiple sclerosis (MS), onset is a subacute clinically isolated syndrome (CIS) of the optic nerves, brainstem, or spinal cord. Methods of assessing the prognosis for patients who present with a CIS have been sought, because only 30-70% of patients with a CIS develop MS. When clinically silent brain lesions are seen on MRI, the likelihood of developing MS is high. MS can be diagnosed within 3 months of CIS presentation with certain MRI and CSF criteria. Disability from MS is less likely in patients with a CIS of optic neuritis or sensory symptoms only, few or no MRI lesions, a long period to the first relapse, and no disability after the first 5 years. Development of more reliable prognostic markers will enable new treatments to be targeted for those who are most likely to benefit. We encourage continued clinical and laboratory assessment of patients with a CIS.
机译：在85％的多发性硬化症（MS）的年轻人中，发作是视神经，脑干或脊髓的亚急性临床孤立综合征（CIS）。由于只有30-70％的CIS患者发展为MS，因此已寻求评估CIS患者的预后的方法。当在MRI上看到临床无症状的脑部病变时，发生MS的可能性很高。可以根据某些MRI和CSF标准在CIS出现后3个月内诊断出MS。仅患有视神经炎或感觉症状的CIS，很少或没有MRI病变，第一次复发的时间较长且在最初5年后没有残疾的患者中，MS的残疾可能性较小。开发更可靠的预后指标将使新的治疗方法针对最有可能受益的患者。我们鼓励对CIS患者进行持续的临床和实验室评估。

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