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首页> 外文期刊>Eastern Journal of Medicine >Protective effect of Ferulago angulata (Schlecht.) Boiss on N-nitrosodimethylamine induced oxidative stress in rats.
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Protective effect of Ferulago angulata (Schlecht.) Boiss on N-nitrosodimethylamine induced oxidative stress in rats.

机译：Ferulago angulata（Schlecht。）Boiss对N-亚硝基二甲胺诱导的大鼠氧化应激的保护作用。

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Protective effect of Ferulago angulata (Schlecht.) Boiss on N-nitrosodimethylamine induced oxidative stress in rats. Hatice K?z?lta?sup1/sup, Suat Ekin sup2/sup, Mahire Bayramo?lu Akkoyunsup3/sup, G?khan Otosup4/sup, Esvet Akba?sup2/sup sup1/supBitlis Eren University, Hizan Myo. Bitlis, Turkey. sup2/supYüzüncü Y?l University. Faculty Of Science, Department Of Chemistry. Van, Turkey. sup3/supSiirt University. Faculty Of Veterinary. Siirt, Turkey. sup4/supYüzüncü Y?l University. Faculty of Medicine, Department of Pharmacology. Van, Turkey. INTRODUCTION: The aim of the present study was to investigate the effect of Ferulago angulata (Schlecht.) Boiss. (FASB) extract on mineral (Ca, K, Na) and trace element (Cu, Zn, Se, Co, Fe, Mn, Cr, Pb, Ni, Cd) levels were determined in rat heart tissue, which was oxidatively stressed with N-nitrosodimethylamine (NDMA). METHODS: Experimental period was continued with Wistar-Albino rats (n: 60) in 21 days. Rats were treated with NDMA (10 mg/kg) in first seven days. FASB plant extract was given to the rats each day of the study. The rats were divided into six groups of ten rats each. The mineral and trace element levels of heart tissue were analyzed by using ICP-OES. RESULTS: The results show that NDMA group was significantly lower results than control group with regarding to Zn, Co and Na levels (p0.05, p0.01 and p0.05). On the other hand the NDMA group was also significantly lower results than the FASB (300 mg/kg) group regarding Zn and Co levels (p0.05 and p0.05), whereas the FASB (150 mg/kg) group had increased level of Na according to NDMA group (p0.05). DISCUSSION AND CONCLUSION: In conclusion, due to the positive effect on significantly alteration in Zn and Co level of heart tissue, it was suggested that the FASB (150, 300 mg/kg) can be used in preventing hearth damage.
机译：Ferulago angulata（Schlecht。）Boiss对N-亚硝基二甲胺诱导的大鼠氧化应激的保护作用。 Hatice K？z？lta？ 1 ，Suat Ekin 2 ，Mahire Bayramo？lu Akkoyun 3 ，G？khan Oto 4 < / sup>，Esvet Akba？ 2 1 Bitlis Eren大学，Hizan Myo。土耳其Bitlis。 2 YüzüncüY？l University。理学院化学系。范，土耳其。 3 西尔特大学。兽医学院。土耳其锡尔特。 4 YüzüncüY？l University。医学院药理学系。范，土耳其。引言：本研究的目的是研究安氏Ferulago Angulata（Schlecht。）Boiss的作用。 （FASB）提取物测定了大鼠心脏组织中矿物质（Ca，K，Na）和微量元素（Cu，Zn，Se，Co，Fe，Mn，Cr，Pb，Ni，Cd）的含量，并用氧化应激N-亚硝基二甲胺（NDMA）。方法：Wistar-Albino大鼠（n：60）在21天内继续进行实验。在开始的七天内，用NDMA（10 mg / kg）治疗大鼠。在研究的每一天，将FASB植物提取物给予大鼠。将大鼠分成六组，每组十只。使用ICP-OES分析心脏组织的矿物质和微量元素水平。结果：就Zn，Co和Na水平而言，NDMA组的结果明显低于对照组（p <0.05，p <0.01和p <0.05）。另一方面，NDMA组的锌和钴水平也显着低于FASB（300 mg / kg）组（p <0.05和p <0.05），而FASB（150 mg / kg）组的水平升高NDMA组的Na含量（p <0.05）。讨论与结论：总而言之，由于对心脏组织中锌和钴水平的显着改变具有积极作用，因此建议将FASB（150，300 mg / kg）用于预防壁炉的损害。

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