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Early detection of cardiotoxicity by 2D and 3D deformation imaging in patients receiving chemotherapy

机译：通过2D和3D变形成像在接受化疗的患者中早期发现心脏毒性

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The aim of the present study was to find out whether early cardiac changes in patients receiving chemotherapy can be detected by the conventional and deformation parameters of 2D and 3D echocardiography. Twenty-five healthy subjects with normal regional left ventricular function (group 1) and 25 patients receiving chemotherapy (group 2) underwent 2D and 3D transthoracic echocardiography (Toshiba Artida Medical System). All patients (group 2) were examined before and during cardiotoxic chemotherapy at a 3-month follow-up. Left ventricular volumes, ejection fraction, muscle mass, global longitudinal, global radial, global circumferential strain, and rotation were analyzed with 2D and 3D echocardiography, while twist and time-to-peak-intervals were analyzed with 3D echocardiography. For left ventricular volumes and muscle mass, no significant differences were seen between the two study groups (P0.05). According to our results, myocardial dysfunction induced by cardiotoxic chemotherapy can be detected by 2D global radial strain. Detecting myocardial dysfunction by global longitudinal and circumferential strain requires more than 3 months follow-up. Changes in rotation, twist or time-to-peak intervals could not be verified at the 3-month follow-up in the present study. 2D global radial strain seems to be the most sensitive and robust parameter to detect early myocardial damage during chemotherapy. 3D echocardiography is not yet an established method to detect myocardial damage in clinical practice due to lower spatial and temporal resolution.
机译：本研究的目的是发现是否可以通过2D和3D超声心动图的常规参数和变形参数来检测接受化疗的患者的早期心脏变化。 25名具有正常区域左心室功能的健康受试者（第1组）和25例接受化疗的患者（第2组）接受了2D和3D经胸超声心动图检查（东芝Artida Medical System）。在心脏毒性化疗之前和期间，对所有患者（第2组）进行了3个月的随访。使用2D和3D超声心动图分析左心室容积，射血分数，肌肉质量，总体纵向，全局径向，全局圆周应变和旋转，同时使用3D超声心动图分析扭曲和峰间时间。对于左心室容积和肌肉质量，两个研究组之间没有发现显着差异（P <0.05）。根据我们的结果，可以通过2D整体放射状应变检测到由心脏毒性化疗引起的心肌功能障碍。通过整体纵向和圆周应变来检测心肌功能障碍需要3个多月的随访。在本研究的3个月随访中，无法验证旋转，扭曲或达到峰值时间间隔的变化。二维整体径向应变似乎是检测化疗期间早期心肌损伤的最敏感和最可靠的参数。由于较低的空间和时间分辨率，3D超声心动图在临床实践中尚未成为检测心肌损伤的成熟方法。

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