• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Iranian Journal of Reproductive Medicine >REACTIVE OXYGEN SPECIES (ROS) PRODUCTION IN SEMINAL FLUID CORRELATE WITH THE SEVERITY OF VARICOCELE IN INFERTILE MEN
【24h】

REACTIVE OXYGEN SPECIES (ROS) PRODUCTION IN SEMINAL FLUID CORRELATE WITH THE SEVERITY OF VARICOCELE IN INFERTILE MEN

机译：男性半精液中活性氧物种（ROS）的产生与精索静脉曲张的严重程度相关

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Reactive oxygen species (ROS) are a group of free radicals that in excessive amounts have negative influence on sperm quality and function.Objective: To study the effect of varicocele and its severity on the level of ROS in infertile men with clinical varicocele.Materials and Methods: In this controlled prospective study, 42 men with clinically diagnosed left varicocele and 30 fertile men were studied. Patients were asked about history of urogenital infection, using any antioxidant medication and smoking. Grade of varicocele was determined by physical examination. Levels of ROS in seminal plasma were measured in each group by a chemiluminiscence assay. The sperm parameters were also determined and compared in different groups.Results: The ROS levels were significantly higher in patients with varicocele than normal men (mean: 1575.42 RLU (Radio Luminescence Unit) vs. 53.79 RLU, p=0.005). In total 20 patients had grade I, 20 patients grade II and 2 patients had grade III varicocele. The mean ROS levels were 669.12 RLU, 2406.87 RLU and 2324 RLU in patients with grade I, II and III varicocele respectively (p=0.144). In case group, 15 patients were smoker and 27 were non-smokers. The mean ROS levels in patients with the history of smoking was 1367.71 RLU while in non-smokers it was 897.672 RLU (p=0.729).Conclusion: Our study showed that increased levels of ROS production in the seminal fluid can be an important factor in the etiology of male infertility in patients with varicocele, and this effect is more prominent with higher grade of varicocele.
机译：背景：活性氧（ROS）是一组自由基，对精子的质量和功能有负面影响。目的：研究精索静脉曲张及其严重程度对不育男性精索静脉曲张的影响。材料和方法：在这项对照前瞻性研究中，研究了42例经临床诊断为左精索静脉曲张的男性和30例可育男性。使用任何抗氧化剂和吸烟方法询问患者泌尿生殖系统感染的病史。通过体检确定精索静脉曲张的等级。通过化学发光测定法在每组中测量精浆中的ROS水平。结果：精索静脉曲张患者的ROS水平显着高于正常男性（平均：1575.42 RLU（放射性发光单位）与53.79 RLU，p = 0.005）。共有20例患者为I级，20例患者为II级，2例患者为III级精索静脉曲张。 I，II和III级精索静脉曲张患者的平均ROS水平分别为669.12 RLU，2406.87 RLU和2324 RLU（p = 0.144）。在病例组中，有15名患者是吸烟者，而27名是非吸烟者。有吸烟史的患者平均ROS水平为1367.71 RLU，而非吸烟者为897.672 RLU（p = 0.729）。精索静脉曲张患者的男性不育症病因，且精索静脉曲张等级越高，这种作用越明显。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号