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首页> 外文期刊>Egyptian Journal of Anaesthesia >Use of ketofol to control emergence agitation in children undergoing adenotonsillectomy
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Use of ketofol to control emergence agitation in children undergoing adenotonsillectomy

机译：酮诺酚用于控制接受腺扁桃体切除术的儿童的急躁情绪的方法

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Objective To assess the efficacy and safety of ketofol administration in controlling emergence agitation (EA) after sevoflurane-based anesthesia in children undergoing adenoidectomy or adenotonsillectomy. Subjects and methods This double-blinded randomized study involved 90 children (3–6 years) scheduled for elective adenotonsillectomy or adenoidectomy. They were randomly assigned to receive 10 ml of normal saline (control group, C) or, 1 mg/kg propofol in 10 ml saline (group P) or ketofol as 1 mg/kg propofol and 0.25 mg/kg ketamine in 10 ml saline (group K) 10 min before the end of surgery. In PACU, sedation, behavior, pain and severity of EA were assessed using modified Aldrete score, Aono’s scale, Objective Pain Score (OPS) and Pediatric Anesthesia Emergence Delirium (PAED) scale, respectively. Results In ketofol group, OPS was significantly lower compared to propofol and control groups. Recovery criteria were in favor of ketofol and propofol groups including longer time to eye opening ( p 0.001) and time to Aldrete score ? 9 ( p = 0.001). Time to discharge from PACU was comparable in the three groups ( p = 0.079). EA was significantly more frequent in the control group ( p 0.001), but comparable in ketofol and propofol groups. PAED score was significantly higher in control group compared to ketofol and propofol groups. Ketofol and propofol preserved hemodynamic stability. Conclusion Ketofol provides a promising new option for controlling emergence agitation with adequate postoperative sedative and analgesic effect, good recovery criteria and hemodynamic stability compared to propofol and control groups in children undergoing adenoidectomy or adenotonsillectomy.
机译：目的评估在进行了腺样体切除术或腺扁桃体切除术的儿童中以七氟醚为基础的麻醉后，在服用七氟醚的情况下，控制服用酮酚的有效性和安全性。受试者和方法这项双盲随机研究涉及90例计划进行腺扁桃腺切除术或腺样体切除术的儿童（3-6岁）。他们被随机分配接受10 ml生理盐水（对照组，C）或1 mg / kg异丙酚的10 ml生理盐水（P组）或ketofol或1 mg / kg异丙酚和0.25 mg / kg氯胺酮的10 ml生理盐水。 （K组）手术结束前10分钟。在PACU中，分别使用改良的Aldrete评分，Aono量表，客观疼痛评分（OPS）和小儿麻醉性紧急Deli妄（PAED）量表评估EA的镇静，行为，疼痛和严重程度。结果酮泊酚组的OPS明显低于丙泊酚和对照组。恢复标准支持酮酚和丙泊酚组，包括更长的睁眼时间（p <0.001）和达到Aldrete评分的时间？ 9（p = 0.001）。三组患者从PACU排出的时间相当（p = 0.079）。对照组中EA的发生频率明显更高（p <0.001），但在酮酚和丙泊酚组中，EA的发生率却相当。对照组的PAED评分显着高于氯酚和丙泊酚组。酮泊酚和丙泊酚可保持血液动力学稳定性。结论与接受异丙酚和腺样体切除术的患儿相比，丙泊酚提供了一种有希望的新选择，可以控制发作性躁动，具有足够的术后镇静和镇痛作用，良好的恢复标准和血液动力学稳定性。

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