...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Endocrine journal >Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism
【24h】

Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism

机译：日本男性2型糖尿病患者血清chemerin水平降低：性别二态性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

References(35) Cited-By(6) Chemerin, a recently discovered adipocytokine plays an important role in obesity and obesity-associated metabolic complications. However, the role of chemerin in the pathogenesis of type 2 diabetes mellitus (T2DM) has not fully been elucidated. We compared the serum chemerin levels and metabolic parameters between 88 control subjects, 86 patients with metabolic syndrome (MS), and 147 patients with T2DM in a Japanese population and further analyzed their correlation. Enzyme-linked immunosorbent assay was used to measure the serum chemerin levels. The chemerin levels were significantly higher in male than in female control subjects (p vs. 209.8 ± 7.7 and 218.7 ± 7.3 ng/mL; p vs. p < 0.0001, respectively) but no significant differences in female subjects. The multiple regression analysis revealed that the chemerin levels negatively correlated with the fasting glucose and HbA1c levels in total and male subjects. In the patients with T2DM, the chemerin levels negatively correlated with fasting glucose and high-density lipoprotein cholesterol but positively correlated with body mass index (BMI), and total cholesterol and triglyceride levels. The negative correlation between the chemerin and fasting glucose levels remained significant after adjustment for age, sex, and BMI in the total and male subjects and those with T2DM. These results suggest the role of chemerin in sex dimorphism and a potential link between chemerin levels and T2DM pathogenesis in a Japanese population.
机译：参考文献（35）Cited-By（6）Chemerin是一种最近发现的脂肪细胞因子，在肥胖和与肥胖相关的代谢并发症中起着重要的作用。但是，chemerin在2型糖尿病（T2DM）发病机理中的作用尚未完全阐明。我们比较了日本人群中88例对照受试者，86例代谢综合征（MS）和147例T2DM患者的血清凯莫瑞水平和代谢参数，并进一步分析了它们的相关性。酶联免疫吸附测定法用于测定血清凯莫瑞水平。男性的凯莫瑞水平显着高于女性对照受试者（p分别为209.8±7.7和218.7±7.3 ng / mL; p vs. p <0.0001），但女性受试者无显着差异。多元回归分析显示，总受试者和男性受试者中凯莫瑞水平与空腹血糖和HbA1c水平呈负相关。在T2DM患者中，凯莫瑞水平与空腹血糖和高密度脂蛋白胆固醇呈负相关，而与体重指数（BMI），总胆固醇和甘油三酸酯水平呈正相关。在对年龄，性别和BMI进行校正后，总和男性受试者以及患有T2DM的受试者中，凯莫瑞和空腹血糖水平之间的负相关性仍然很显着。这些结果表明，chemerin在性别二态性中的作用，以及chemerin水平与日本人群T2DM发病机制之间的潜在联系。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号