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首页> 外文期刊>Endocrine journal >Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism
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Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism

机译：日本男性2型糖尿病患者血清chemerin水平降低：性别二态性

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摘要

Chemerin, a recently discovered adipocytokine plays an important role in obesity and obesity-associated metabolic complications. However, the role of chemerin in the pathogenesis of type 2 diabetes mellitus (T2DM) has not folly been elucidated. We compared the serum chemerin levels and metabolic parameters between 88 control subjects, 86 patients with metabolic syndrome (MS), and 147 patients with T2DM in a Japanese population and further analyzed their correlation. Enzyme-linked immunosorbent assay was used to measure the serum chemerin levels. The chemerin levels were significantly higher in the male than in the female control subjects (p < 0.005), with significant decreases in the patients with T2DM compared with those with MS and the control subjects (164.9 ± 6.3 ng/mL vs. 209.8 ± 7.7 and 218.7 ± 7.3 ng/mL; p < 0.0001 vs. p < 0.0001, respectively) but no significant differences in the female subjects. The multiple regression analysis revealed that the chemerin levels negatively correlated with the fasting glucose and HbAlc levels in the total and male subjects. In the patients with T2DM, the chemerin levels negatively correlated with fasting glucose and high-density lipoprotein cholesterol but positively correlated with body mass index (BMI), and total cholesterol and triglyceride levels. The negative correlation between the chemerin and fasting glucose levels remained significant after adjustment for age, sex, and BMI in the total and male subjects and those with T2DM. These results suggest the role of chemerin in sex dimorphism and a potential link between chemerin levels and T2DM pathogenesis in a Japanese population.
机译：Chemerin是一种最近发现的脂肪细胞因子，在肥胖和肥胖相关的代谢并发症中起着重要的作用。然而，chemerin在2型糖尿病（T2DM）发病机理中的作用尚不清楚。我们比较了日本人群中88例对照受试者，86例代谢综合征（MS）和147例T2DM患者的血清凯莫瑞水平和代谢参数，并进一步分析了它们的相关性。酶联免疫吸附试验用于测量血清凯莫瑞水平。男性的凯莫瑞水平显着高于女性对照组（p <0.005），与MS和对照组相比，T2DM患者的凯莫瑞水平显着降低（164.9±6.3 ng / mL vs. 209.8±7.7）和218.7±7.3 ng / mL；分别为p <0.0001和p <0.0001），但在女性受试者中没有显着差异。多元回归分析显示，总受试者和男性受试者中凯莫瑞水平与空腹血糖和HbAlc水平呈负相关。在T2DM患者中，凯莫瑞水平与空腹血糖和高密度脂蛋白胆固醇呈负相关，而与体重指数（BMI），总胆固醇和甘油三酸酯水平呈正相关。在对年龄，性别和BMI进行调整后，总和男性受试者以及患有T2DM的受试者中，凯莫瑞和空腹血糖水平之间的负相关性仍然很显着。这些结果表明，chemerin在性别二态性中的作用以及chemerin水平与日本人群T2DM发病机制之间的潜在联系。

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  • 来源
    《Endocrine journal》 |2013年第1期|37-44|共8页
  • 作者

    Michiko Takahashi; Sumie Inomata; Yasuhiko Okimura; Genzo Iguchi; Hidenori Fukyoka; Kazuaki Miyake; Daisuke Koga; Suguru Akamatsu; Masato Kasuga; Yutaka Takahashi;

  • 作者单位

    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan;

    Osaka Chuo Japan Post Health Care Center, Osaka 530-8799, Japan;

    Department of Nutrition, Metabolism and Food Science, Kobe Women's University Graduate School of Life Science, Kobe 654-8585, Japan;

    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan;

    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan;

    Internal Medicine, Miki Sanyo Hospital, Miki 673-0501, Japan;

    Department of Research and Development Diagnostic Division, Otsuka Pharmaceutical Co., Ltd., Tokyo 101-8535, Japan;

    Department of Research and Development Diagnostic Division, Otsuka Pharmaceutical Co., Ltd., Tokyo 101-8535, Japan;

    Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan;

    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki- cho, Chuo-ku, Kobe 650-0017 Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    chemerin; diabetes; type 2 diabetes mellitus (T2DM); japanese population;

    机译：凯莫瑞糖尿病;2型糖尿病（T2DM）;日本人口;

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