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首页> 外文期刊>Epigenetics & Chromatin >Yeast Sgf73/Ataxin-7 serves to anchor the deubiquitination module into both SAGA and Slik(SALSA) HAT complexes
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Yeast Sgf73/Ataxin-7 serves to anchor the deubiquitination module into both SAGA and Slik(SALSA) HAT complexes

机译：酵母Sgf73 / Ataxin-7可将脱泛素模块锚定在SAGA和Slik（SALSA）HAT复合物中

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Spinocerebellar ataxia (SCA) is a physically devastating, genetically inherited disorder characterized by abnormal brain function that results in the progressive loss of the ability to coordinate movements. There are many types of SCAs as there are various gene mutations that can cause this disease. SCA types 1–3, 6–10, 12, and 17 result from a trinucleotide repeat expansion in the DNA-coding sequence. Intriguingly, recent work has demonstrated that increased trinucleotde expansions in the SCA7 gene result in defect in the function of the SAGA histone acetyltransferase complex. The SCA7 gene encodes a subunit of the SAGA complex. This subunit is conserved in yeast as the SGF73 gene. We demonstrate that Sgf73 is required to recruit the histone deubiquitination module into both SAGA and the related SliK(SALSA) complex, and to maintain levels of histone ubiquitination, which is necessary for regulation of transcription at a number of genes.
机译：脊髓小脑性共济失调（SCA）是一种具有破坏性的遗传遗传疾病，其特征是大脑功能异常，导致协调运动能力逐渐丧失。 SCA的类型很多，因为有多种基因突变可以导致这种疾病。 SCA类型1–3、6–10、12和17是DNA编码序列中三核苷酸重复扩增的结果。有趣的是，最近的研究表明，SCA7基因中增加的三核苷酸扩展导致SAGA组蛋白乙酰基转移酶复合物功能的缺陷。 SCA7基因编码SAGA复合体的一个亚基。该亚基在酵母中作为SGF73基因保守。我们证明，Sgf73需要将组蛋白去泛素化模块募集到SAGA和相关的SliK（SALSA）复合体中，并保持组蛋白泛素化水平，这对于调节许多基因的转录是必需的。

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