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首页> 外文期刊>Epilepsy & Behavior Case Reports >“EEG abnormalities” may represent a confounding factor in celiac disease: A 4-year follow-up family report
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“EEG abnormalities” may represent a confounding factor in celiac disease: A 4-year follow-up family report

机译：“ EEG异常”可能代表了乳糜泻的混杂因素：4年的随访家庭报告

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Objective The occurrence of celiac disease (CD), electroencephalographic (EEG) abnormalities (with “subtle” seizures or even without any clinical seizures), and neurological disorders has been reported since the 1980s, though there has been no definitive consensus about the possible causal relationship. This topic is further complicated by the occurrence in infancy of ‘clinical–EEG pictures’ called ‘benign epilepsy of infancy’. Methods and results Here, we report a 4-year follow-up on two siblings with newly diagnosed biopsy-proven celiac disease showing EEG abnormalities not responsive to a gluten-free diet. Conclusions This family report indicates that in patients with neurologically asymptomatic CD and EEG abnormalities, it is advisable to make a differential diagnosis between EEG abnormalities associated with CD and an incidental association with cortical hyperexcitability, with “subtle” seizures or even without any clinical seizures. Practice implications A long follow-up may sometimes be required, as it was in the family described here, to clarify the etiopathogenetic and therapeutic relationships between clinical and EEG features in CD.
机译：目的自1980年代以来，已有关于腹腔疾病（CD），脑电图（EEG）异常（“轻微”癫痫发作甚至无任何临床癫痫发作）和神经系统疾病的报道，尽管尚未就可能的因果关系达成共识关系。婴儿期出现的“临床–脑电图图片”（称为“婴儿期良性癫痫”）使这一话题更加复杂。方法和结果在这里，我们报告了两个兄弟姐妹对新诊断的经活组织检查证实的乳糜泻进行了为期4年的随访，显示出对无麸质饮食无反应的脑电图异常。结论该家庭报告表明，对于神经系统无症状的CD和EEG异常的患者，建议对CD引起的EEG异常与皮质过度兴奋性，“轻微”发作甚至无临床发作的偶然关联进行鉴别诊断。实践的意义有时可能需要长时间的随访，以阐明CD的临床特征和脑电图特征之间的病因和治疗关系。

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