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首页> 外文期刊>European Journal of Veterinary Medicine >Evaluation of the cytotoxic response in the treatment of transmisible venereal tumor in dogs by using bleomicin or vincristine
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Evaluation of the cytotoxic response in the treatment of transmisible venereal tumor in dogs by using bleomicin or vincristine

机译：博来霉素和长春新碱对犬传染性性病的细胞毒性反应评价

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The objective of this work is to evaluate the efficiency of bleomecyne sulfate via subcutaneous or intratumural in the treatment of this tumor, comparing the results reached with the obtained from the use of vincristine sulfate. For this purpose, it was selected 15 dogs which confirmed TVT wounds through cytological and/or histological examinations, therefore they were divided in three in group of five animals. The patients of control group (G1) have received a dose of 0,75 mg/m2/IV of vincristine sulfate. The patients of group G2 have been submitted to a treatment using a dose of 0,4UI/kg of bleomycin sulfate intratumoral, while the dogs of group G3 have received a dose of 0,4UI/kg of bleomycin sulfate subcutaneous. In the patients of group G1 the cytoreduction happened gradually according to the sections, and in four of the five dogs there was a complete remission after the fifth session of antineoplastic chemotherapy, resulting in a meaningful statistic difference (p<0,05) when compared with the results of group G3. However, the dogs of group G3 presented cytoreduction only after the first session, which was not observed in second, third and fourth sessions, the moment that the tumors kept stable, and started to growth in the fifth and sixth application. The dogs of G2 have presented an important remission after the firth session, however, in the second and the third and fourth session the tumors have kept stable and after the fifth and sixth applications have presented a slightly regression. The best result, were observed with the administration of vincristine sulfate, however, new studies must be accomplished to improve the efficiency of bleomycin sulfate in the treatment of TVT. An option that must be better studied is the use of intratumural bleomycine in cases of TVT that have already been treated and have presented resistance to the use of vincristine sulfate.
机译：这项工作的目的是评估通过皮下或肿瘤内硫酸布洛美西汀治疗该肿瘤的效率，并与使用硫酸长春新碱所获得的结果进行比较。为此，选择了15只通过细胞学和/或组织学检查证实TVT伤口的狗，因此将它们分成三只，每只五只动物。对照组（G1）的患者接受硫酸长春新碱的剂量为0.75 mg / m 2 / IV。 G2组的患者已经接受了0.4UI / kg硫酸博来霉素瘤内剂量的治疗，而G3组的狗皮下接受了0.4UI / kg硫酸博来霉素的剂量。在G1组患者中，根据切片的不同，细胞减少的过程逐渐发生，并且在五只狗中，有五只在第五次抗肿瘤化疗后完全缓解，与之相比，产生了有意义的统计学差异（p <0.05） G3组的结果。然而，G3组的狗仅在第一阶段之后才出现细胞减少，在肿瘤保持稳定的那一刻在第二，第三和第四阶段没有观察到，并在第五和第六次施用中开始生长。 G2的狗在第一个疗程后表现出重要的缓解，但是，在第二，第三和第四疗程中，肿瘤保持稳定，并且在第五和第六次施用后略有消退。用硫酸长春新碱可观察到最佳结果，但是，必须完成新的研究以提高硫酸博来霉素治疗TVT的效率。必须进行更好研究的选择是在已经治疗且对硫酸长春新碱产生耐药性的TVT病例中使用瘤内博来霉素。

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