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首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >Antibacterial Effects of Leaf Extract of Nandina domestica and the Underlined Mechanism
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Antibacterial Effects of Leaf Extract of Nandina domestica and the Underlined Mechanism

机译：南天竹叶提取物的抑菌作用及其机制

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Aim. The study was conducted to investigate the antibacterial and antiasthmatic effects of Nandina domestica leaf extract, to find out its active components, and to assess its safety issue. Methods. (1) Solid-phase agar dilution method was used for antibacterial activity test of nandina leaf extract and the change of bacterial morphology after treatment was observed under the transmission microscope; (2) guinea pig model of asthma was used to test the asthma prevention effect of nandina leaf extract; (3) alkaloids and flavones were separated from nandina leaf extract and were further analyzed with HPLC-MS; (4) mice model was used to assessment of the safety issue of nandina leaf extract. Results. (1) Nandina leaf extract inhibited the growth of bacteria and destroyed bacterial membrane; (2) nandina leaf extract alleviated animal allergy and asthma; (3) the components reextracted by ethyl acetate were active, in which alkaloids inhibited Gram-positive bacteria and prevented asthma and flavones inhibited Gram-negative bacteria; (4) nandina leaf extract had no toxic effect on mice. Conclusion. Nandina leaves inhibit bacterial growth and prevent asthma through alkaloids and flavones, which had integrated function against chronic bronchitis. This study provided theoretical basement for producing new Chinese medicine against chronic bronchitis.
机译：目标。该研究旨在调查南天竹叶提取物的抗菌和平喘作用，找出其有效成分，并评估其安全性。方法。 （1）采用固相琼脂稀释法对楠竹叶提取物进行抗菌活性测试，并在透射显微镜下观察处理后细菌形态的变化; （2）用豚鼠哮喘模型测试了楠竹叶提取物对哮喘的预防作用; （3）从楠竹叶提取物中分离出生物碱和黄酮，并用HPLC-MS进行进一步分析; （4）用小鼠模型评估了楠竹叶提取物的安全性。结果。 （1）南迪娜叶提取物抑制细菌生长，破坏细菌膜; （2）楠迪叶提取物减轻动物过敏和哮喘病; （3）乙酸乙酯提取的成分具有活性，生物碱抑制革兰氏阳性菌，预防哮喘，黄酮抑制革兰氏阴性菌。 （4）楠竹叶提取物对小鼠无毒性作用。结论。南地那叶通过生物碱和黄酮具有抑制慢性支气管炎的综合功能，可抑制细菌生长并预防哮喘。该研究为生产抗慢性支气管炎的中药提供了理论依据。

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