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首页> 外文期刊>Genes and Nutrition >Complex interaction between serum folate levels and genetic polymorphisms in folate pathway genes: biomarkers of prostate cancer aggressiveness
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Complex interaction between serum folate levels and genetic polymorphisms in folate pathway genes: biomarkers of prostate cancer aggressiveness

机译：血清叶酸水平与叶酸途径基因的遗传多态性之间的复杂相互作用：前列腺癌侵袭性的生物标志物

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Little is known about the role of folate and polymorphisms associated with folate metabolism on prostate cancer risk in populations of African origin. We examined the relationship between serum folate and prostate cancer and whether any association was modified by genetic polymorphisms for folate metabolism. The study was case–control in design and consisted of 218 men 40–80?years old with newly diagnosed, histologically confirmed prostate cancer and 236 cancer-free men attending the same urology clinics in Jamaica, March 2005–July 2007. Serum folate was measured by an immunoassay method and genomic DNA evaluated for MTHR (C677T and A1298C), MTRR A66G, and MTR A2756G polymorphisms. Mean serum folate concentration was higher among cases (12.3?±?4.1?nmol/L) than controls (9.7?±?4.2?nmol/L). Serum folate concentration showed a positive association with prostate cancer (OR, 4.41; CI, 2.52–7.72 per 10?nmol/L) regardless of grade. No interactions were observed between genotype and folate concentration, but a weak gene effect was observed for MTHFR A1298C and low-grade prostate cancer. Larger studies to investigate the role of gene–gene/gene–diet interactions in Black men are needed.
机译：关于叶酸和与叶酸代谢有关的多态性对非洲裔人群前列腺癌风险的作用知之甚少。我们检查了血清叶酸与前列腺癌之间的关系以及叶酸代谢的遗传多态性是否改变了任何关联。该研究采用病例对照设计，研究对象为218名40-80岁的男性，新诊断，经组织学证实为前列腺癌，以及236名在牙买加于2005年3月至2007年7月在同一泌尿科门诊就诊的无癌男性。通过免疫测定方法进行检测，并评估MTHR（C677T和A1298C），MTRR A66G和MTR A2756G多态性的基因组DNA。病例中的平均血清叶酸浓度（12.3±±4.1μmol/ L）高于对照组（9.7±±4.2μmol/ L）。血清叶酸浓度与前列腺癌呈正相关（OR，4.41; CI，每10？nmol / L，2.52-7.72），而与年级无关。没有观察到基因型和叶酸浓度之间的相互作用，但是对于MTHFR A1298C和低度前列腺癌观察到了弱的基因作用。需要进行更大的研究来研究基因-基因/基因-饮食相互作用在黑人中的作用。

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