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Genome-wide analysis of {DNA} methylation associated with {HIV} infection based on a pair of monozygotic twins

机译：基于一对单卵双胞胎的与{HIV}感染相关的{DNA}甲基化的全基因组分析

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Abstract Alteration of {DNA} methylation in mammalian cells could be elicited by many factors, including viral infections [1]. {HIV} has shown the ability to interact with host cellular factors to change the methylation status of some genes [2–4]. However, the change of the {DNA} methylation associated with {HIV} infection based on the whole genome has not been well illustrated. In this study, a unique pair of monozygotic twins was recruited: one of the twins was infected with {HIV} without further anti-retroviral therapy while the other one was healthy, which could be considered as a relatively ideal model for profiling the alterations of {DNA} methylation associated with {HIV} infection. Therefore, using methylated {DNA} immunoprecipitation–microarray method (MeDIP–microarray), we found the increased {DNA} methylation level in peripheral blood mononuclear cells from {HIV} infected twin compared to her normal sibling. Moreover, several distinguished differential methylation regions (DMRs) in {HIV} infected twin worth further study. The raw data has been deposited in Gene Expression Omnibus (GEO) datasets with reference number GSE68028.
机译：摘要哺乳动物细胞中{DNA}甲基化的改变可通过多种因素引起，包括病毒感染[1]。 {HIV}已显示出与宿主细胞因子相互作用以改变某些基因的甲基化状态的能力[2-4]。然而，基于整个基因组的与{HIV}感染相关的{DNA}甲基化的变化还没有很好地说明。在这项研究中，招募了一对独特的单卵双胞胎双胞胎：其中一对双胞胎在没有进一步抗逆转录病毒疗法的情况下感染了{HIV}，而另一对则是健康的，这可以被认为是一个比较理想的模型来描述与{HIV}感染相关的{DNA}甲基化。因此，使用甲基化的{DNA}免疫沉淀-微阵列方法（MeDIP-微阵列），我们发现{HIV}感染双胞胎的外周血单核细胞中的{DNA}甲基化水平高于正常兄弟姐妹。此外，{HIV}感染的双胞胎中的几个显着的差异甲基化区域（DMR）值得进一步研究。原始数据已存储在Gene Expression Omnibus（GEO）数据集中，参考号为GSE68028。

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