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首页> 外文期刊>Genomics >Comparison of pathways associated with hepatitis B- and C-infected hepatocellular carcinoma using pathway-based class discrimination method
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Comparison of pathways associated with hepatitis B- and C-infected hepatocellular carcinoma using pathway-based class discrimination method

机译：基于途径的类别鉴别方法比较与乙型和丙型肝炎感染的肝细胞癌相关的途径

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Molecular signatures causing hepatocellular carcinoma (HCC) from chronic infection of hepatitis B virus (HBV) or hepatitis C virus (HCV) are not clearly known. Using microarray datasets composed of HCV-positive HCC or HBV-positive HCC, pathways that could discriminate tumor tissue from adjacent non-tumor liver tissue were selected by implementing nearest shrunken centroid algorithm. Cancer-related signaling pathways and lipid metabolism-related pathways were predominantly enriched in HCV-positive HCC, whereas functionally diverse pathways including immune-related pathways, cell cycle pathways, and RNA metabolism pathways were mainly enriched in HBV-positive HCC. In addition to differentially involved pathways, signaling pathways such as TGF-β, MAPK, and p53 pathways were commonly significant in both HCCs, suggesting the presence of common hepatocarcinogenesis process. The pathway clustering also verified segregation of pathways into the functional subgroups in both HCCs. This study indicates the functional distinction and similarity on the pathways implicated in the development of HCV- and/or HBV-positive HCC.
机译：尚不清楚由慢性感染乙型肝炎病毒（HBV）或丙型肝炎病毒（HCV）引起肝细胞癌（HCC）的分子特征。使用由HCV阳性HCC或HBV阳性HCC组成的微阵列数据集，通过实施最近的收缩质心算法，选择可以将肿瘤组织与相邻的非肿瘤肝组织区分开的途径。 HCV阳性HCC主要富集与癌症相关的信号通路和脂质代谢相关的途径，而HBV阳性HCC主要富集功能多样的途径，包括免疫相关途径，细胞周期途径和RNA代谢途径。除了差异参与的途径外，两个HCC中的信号传导途径（例如TGF-β，MAPK和p53途径）通常也很重要，表明存在共同的肝癌发生过程。途径聚类也验证了两个HCC中途径向功能亚组的分离。这项研究表明，HCV和/或HBV阳性HCC的发展过程中所涉及途径的功能差异和相似性。

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