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Skin anti‐inflammatory activity of rose petal extract ( Rosa gallica ) through reduction of MAPK signaling pathway

机译：玫瑰花瓣提取物（Rosa gallica）通过减少MAPK信号通路的皮肤抗炎活性

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The aim of this study was to investigate the skin anti‐inflammatory activity of rose petal extract (RPE) and the mechanisms underlying this phenomenon. Recently, flowers have been considered as dietary resources owing to their biological activities, such as inhibition of nephritis and hemorrhoids. The Rosa plant exerts various biological functions, including antioxidant and anti‐microbiological activities. Herein, we confirmed the skin anti‐inflammatory activity of RPE upon solar UV (sUV) exposure. RPE reduced sUV‐induced COX‐2 expression as well as expressions of several cytokines. Activation of MKK4‐JNK, MEK‐ERK, and MKK3‐p38 signaling pathways, which are associated with cytokine production, was also attenuated by RPE treatment. We hypothesized these RPE‐induced changes are because of its antioxidant activity, because RPE displayed drastic radical scavenging and oxygen radical absorbance capacity (ORAC). Furthermore, high anthocyanins, polyphenols, and flavonoids contents were found in RPE. Hence, these results indicated the skin anti‐inflammatory activity of RPE is because of antioxidant activity.
机译：这项研究的目的是研究玫瑰花瓣提取物（RPE）的皮肤抗炎活性及其潜在机制。最近，由于花朵具有生物学活性，例如抑制肾炎和痔疮，它们被认为是饮食资源。罗莎植物具有多种生物学功能，包括抗氧化剂和抗微生物活性。在此，我们证实了RPE在太阳紫外线（sUV）照射下具有皮肤抗炎活性。 RPE降低了sUV诱导的COX-2表达以及几种细胞因子的表达。 RPE处理也减弱了与细胞因子产生相关的MKK4-JNK，MEK-ERK和MKK3-p38信号通路的激活。我们假设这些RPE引起的变化是由于其抗氧化活性，因为RPE表现出急剧的自由基清除和氧自由基吸收能力（ORAC）。此外，在RPE中发现了较高的花色苷，多酚和类黄酮含量。因此，这些结果表明RPE的皮肤抗炎活性是由于抗氧化活性。

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