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首页> 外文期刊>Frontiers in Endocrinology >Growth Hormone-Releasing Hormone in Diabetes
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Growth Hormone-Releasing Hormone in Diabetes

机译：糖尿病中生长激素释放激素

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Growth hormone-releasing hormone (GHRH) is produced by the hypothalamus and stimulates growth hormone synthesis and release in the anterior pituitary gland. In addition, GHRH is an important regulator of cellular functions in many cells and organs. Expression of GHRH G-Protein Coupled Receptor (GHRHR) has been demonstrated in different peripheral tissues and cell types, including pancreatic islets. Among the peripheral activities, recent studies demonstrate a novel ability of GHRH analogs to increase and preserve insulin secretion by beta-cells in isolated pancreatic islets, which makes them potentially useful for diabetes treatment. This review considers the role of GHRHR in the beta-cell and addresses the unique engineered GHRH agonists and antagonists for treatment of type 2 diabetes mellitus. We discuss the similarity of signaling pathways activated by GHRHR in pituitary somatotrophs and in pancreatic beta-cells and possible ways as to how the GHRHR pathway can interact with glucose and other secretagogues to stimulate insulin secretion. We also consider the hypothesis that novel GHRHR agonists can improve glucose metabolism in Type 2 diabetes by preserving the function and survival of pancreatic beta-cells. Wound healing and cardioprotective action with new GHRH agonists suggest that they may prove useful in ameliorating certain diabetic complications. These findings highlight the future potential therapeutic effectiveness of modulators of GHRHR activity for the development of new therapeutic approaches in diabetes and its complications.
机译：下丘脑产生生长激素释放激素（GHRH），并刺激垂体前叶腺中生长激素的合成和释放。此外，GHRH是许多细胞和器官中细胞功能的重要调节剂。 GHRH G蛋白偶联受体（GHRHR）的表达已在不同的外周组织和细胞类型（包括胰岛）中得到证实。在周围的活动中，最近的研究表明GHRH类似物具有增加和保留胰岛胰岛β细胞分泌胰岛素的新能力，这使其有可能用于糖尿病治疗。这篇评论考虑了GHRHR在β细胞中的作用，并探讨了用于治疗2型糖尿病的独特工程改造的GHRH激动剂和拮抗剂。我们讨论了由GHRHR激活的垂体生长激素和胰腺β细胞中信号通路的相似性，以及GHRHR通路如何与葡萄糖和其他促分泌素相互作用以刺激胰岛素分泌的可能途径。我们还考虑了这样的假设，即新型GHRHR激动剂可以通过保留胰腺β细胞的功能和存活来改善2型糖尿病的葡萄糖代谢。新型GHRH激动剂的伤口愈合和心脏保护作用表明，它们可能被证明可改善某些糖尿病并发症。这些发现强调了GHRHR活性调节剂对于糖尿病及其并发症的新治疗方法的开发的潜在潜在治疗效力。

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